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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NXT2

Summary for NXT2

Gene information	Gene symbol	NXT2
	Ensembl ID	ENSG00000101888
	Entrez ID	55916
	Gene name	nuclear transport factor 2 like export factor 2
	Synonyms	P15-2
	Gene type	protein_coding
	UniProtAcc	Q9NPJ8

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Dataset with differentially expressed gene: NXT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.510213	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.283147	1.03e-12
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.35001	1.29e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.350699	3.55e-15
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.337036	0.00e+00

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Expression of NXT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NXT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NXT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NXT2	hsa-miR-137-3p	99.0383	NM_001242617
NXT2	hsa-miR-9-3p	98.8506	NM_001242618
NXT2	hsa-miR-3148	97.9111	NM_001242618
NXT2	hsa-miR-320b	97.3897	NM_001242617
NXT2	hsa-miR-320c	97.3897	NM_001242617
NXT2	hsa-miR-4429	97.3897	NM_001242617
NXT2	hsa-miR-320d	97.3897	NM_001242617
NXT2	hsa-miR-320a-3p	97.3897	NM_001242617
NXT2	hsa-miR-6124	97.1912	NM_001242618
NXT2	hsa-miR-206	96.4517	NM_001242618
NXT2	hsa-miR-1-3p	96.4517	NM_001242618
NXT2	hsa-miR-613	96.4487	NM_001242618
NXT2	hsa-miR-5692a	96.4174	NM_001242618
NXT2	hsa-miR-6512-3p	95.4437	NM_001242618
NXT2	hsa-miR-6720-5p	95.4437	NM_001242618
NXT2	hsa-miR-624-5p	94.4896	NM_001242618
NXT2	hsa-miR-216a-3p	93.5215	NM_001242617
NXT2	hsa-miR-128-3p	93.5215	NM_001242617
NXT2	hsa-miR-4776-5p	93.3293	NM_001242618
NXT2	hsa-miR-548at-5p	91.8412	NM_001242618
NXT2	hsa-miR-3910	91.5393	NM_001242617
NXT2	hsa-miR-9985	91.4346	NM_001242617
NXT2	hsa-miR-27a-3p	91.4346	NM_001242617
NXT2	hsa-miR-27b-3p	91.4346	NM_001242617
NXT2	hsa-miR-3681-3p	90.7621	NM_001242617
NXT2	hsa-miR-524-5p	90.5759	NM_001242617
NXT2	hsa-miR-520d-5p	90.5759	NM_001242617
NXT2	hsa-miR-7-5p	90.4017	NM_001242617
NXT2	hsa-miR-8060	89.8744	NM_001242618
NXT2	hsa-miR-6739-3p	88.8194	NM_001242618
NXT2	hsa-miR-450b-5p	87.4622	NM_001242618
NXT2	hsa-miR-6882-5p	87.0023	NM_001242618
NXT2	hsa-miR-4694-3p	86.0587	NM_001242618
NXT2	hsa-miR-449c-3p	85.6025	NM_001242617
NXT2	hsa-miR-554	85.0844	NM_001242618
NXT2	hsa-miR-656-3p	84.2814	NM_001242618
NXT2	hsa-miR-12136	84.1074	NM_001242618
NXT2	hsa-miR-4797-5p	83.4485	NM_001242618
NXT2	hsa-miR-4677-5p	83.056	NM_001242618
NXT2	hsa-let-7f-2-3p	82.7186	NM_001242618
NXT2	hsa-miR-1185-2-3p	82.7186	NM_001242618
NXT2	hsa-miR-1185-1-3p	82.7186	NM_001242618
NXT2	hsa-miR-126-5p	82.6317	NM_001242618
NXT2	hsa-miR-4503	82.5299	NM_001242618
NXT2	hsa-miR-10226	81.8199	NM_001242618
NXT2	hsa-miR-7854-3p	81.7124	NM_001242618
NXT2	hsa-miR-218-5p	81.3206	NM_001242617
NXT2	hsa-miR-4291	80.4363	NM_001242618

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Motifs and transcription factors (TFs) regulating NXT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NXT2	jaspar__MA1933.1	SREBF2 (directAnnotation).
NXT2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
NXT2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NXT2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
NXT2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NXT2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
NXT2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
NXT2	hdpi__ETV4	ETV4 (directAnnotation).
NXT2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
NXT2	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
NXT2	cisbp__M02645	ETS1 (directAnnotation).
NXT2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
NXT2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
NXT2	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
NXT2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
NXT2	jaspar__MA1483.2	ELF2 (directAnnotation).
NXT2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
NXT2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
NXT2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
NXT2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
NXT2	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
NXT2	cisbp__M08198	ELF1 (directAnnotation).
NXT2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
NXT2	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
NXT2	hdpi__TP73	TP73 (directAnnotation).
NXT2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
NXT2	hdpi__FLI1	FLI1 (directAnnotation).
NXT2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
NXT2	transfac_pro__M04950	EGR1 (directAnnotation).
NXT2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
NXT2	transfac_pro__M04826	EP300 (directAnnotation).
NXT2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
NXT2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
NXT2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
NXT2	hdpi__ELF2	ELF2 (directAnnotation).
NXT2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
NXT2	metacluster_183.4	ETS1 (inferredBy_Orthology).
NXT2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
NXT2	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
NXT2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
NXT2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
NXT2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
NXT2	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
NXT2	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
NXT2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
NXT2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."