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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NUS1

Summary for NUS1

Gene information	Gene symbol	NUS1
	Ensembl ID	ENSG00000153989
	Entrez ID	116150
	Gene name	NUS1 dehydrodolichyl diphosphate synthase subunit
	Synonyms	C6orf68\|MGC7199\|NgBR\|TANGO14
	Gene type	protein_coding
	UniProtAcc	Q96E22

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Dataset with differentially expressed gene: NUS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.387223	3.74e-34
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.258503	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.328843	4.37e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.279419	1.46e-35
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.303511	1.52e-09
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.450865	8.31e-14

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Expression of NUS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NUS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NUS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NUS1	hsa-miR-1297	98.5267	NM_138459
NUS1	hsa-miR-153-5p	97.6942	NM_138459
NUS1	hsa-miR-548c-3p	96.6899	NM_138459
NUS1	hsa-miR-5587-5p	96.1449	NM_138459
NUS1	hsa-miR-26a-5p	95.8127	NM_138459
NUS1	hsa-miR-26b-5p	95.8127	NM_138459
NUS1	hsa-miR-513c-3p	95.6384	NM_138459
NUS1	hsa-miR-513a-3p	95.6384	NM_138459
NUS1	hsa-miR-4262	95.4869	NM_138459
NUS1	hsa-miR-4465	95.0011	NM_138459
NUS1	hsa-miR-3606-3p	94.2544	NM_138459
NUS1	hsa-miR-181b-5p	94.2519	NM_138459
NUS1	hsa-miR-181d-5p	94.2519	NM_138459
NUS1	hsa-miR-181c-5p	94.2519	NM_138459
NUS1	hsa-miR-181a-5p	94.2519	NM_138459
NUS1	hsa-miR-23a-3p	93.857	NM_138459
NUS1	hsa-miR-23b-3p	93.857	NM_138459
NUS1	hsa-miR-23c	93.857	NM_138459
NUS1	hsa-miR-4282	93.5544	NM_138459
NUS1	hsa-miR-6513-3p	93.5348	NM_138459
NUS1	hsa-miR-6853-3p	92.0847	NM_138459
NUS1	hsa-miR-584-3p	92.0756	NM_138459
NUS1	hsa-miR-184	91.8282	NM_138459
NUS1	hsa-miR-4804-5p	91.5461	NM_138459
NUS1	hsa-miR-95-5p	91.5367	NM_138459
NUS1	hsa-miR-216a-3p	91.2177	NM_138459
NUS1	hsa-miR-128-3p	91.2177	NM_138459
NUS1	hsa-miR-3681-3p	91.1704	NM_138459
NUS1	hsa-miR-9983-3p	91.0437	NM_138459
NUS1	hsa-miR-641	90.9011	NM_138459
NUS1	hsa-miR-3617-5p	90.9011	NM_138459
NUS1	hsa-miR-3671	90.6136	NM_138459
NUS1	hsa-miR-4775	89.9841	NM_138459
NUS1	hsa-miR-129-5p	89.9309	NM_138459
NUS1	hsa-miR-3161	89.5905	NM_138459
NUS1	hsa-miR-96-5p	89.4365	NM_138459
NUS1	hsa-miR-4457	88.6983	NM_138459
NUS1	hsa-miR-3613-3p	88.5705	NM_138459
NUS1	hsa-miR-337-3p	88.3593	NM_138459
NUS1	hsa-miR-4286	88.3274	NM_138459
NUS1	hsa-miR-5010-3p	87.8836	NM_138459
NUS1	hsa-miR-12133	87.5132	NM_138459
NUS1	hsa-miR-589-3p	87.167	NM_138459
NUS1	hsa-miR-1271-5p	86.9919	NM_138459
NUS1	hsa-miR-205-3p	86.4717	NM_138459
NUS1	hsa-miR-30c-5p	85.4071	NM_138459
NUS1	hsa-miR-30a-5p	85.4071	NM_138459
NUS1	hsa-miR-30d-5p	85.4071	NM_138459
NUS1	hsa-miR-30b-5p	85.4071	NM_138459
NUS1	hsa-miR-30e-5p	85.4071	NM_138459

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Motifs and transcription factors (TFs) regulating NUS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NUS1	metacluster_52.11	ZNF184 (directAnnotation).
NUS1	metacluster_98.1	ZNF524 (directAnnotation).
NUS1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NUS1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NUS1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
NUS1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
NUS1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
NUS1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
NUS1	transfac_pro__M04918	EGR1 (directAnnotation).
NUS1	transfac_pro__M04826	EP300 (directAnnotation).
NUS1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
NUS1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
NUS1	metacluster_144.12	ZNF419; ZNF773 (directAnnotation).
NUS1	kznf__ZNF343_Imbeault2017_RP_RCADE	ZNF343 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."