Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NUP58

Summary for NUP58

Gene information	Gene symbol	NUP58
	Ensembl ID	ENSG00000139496
	Entrez ID	9818
	Gene name	nucleoporin 58
	Synonyms	KIAA0410\|NUP45\|NUPL1
	Gene type	protein_coding
	UniProtAcc	Q9BVL2

Top

Dataset with differentially expressed gene: NUP58

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.377837	8.18e-36

Top

Expression of NUP58 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NUP58

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NUP58

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NUP58	hsa-miR-548aw	96.8298	NM_001008564
NUP58	hsa-miR-1323	95.7038	NM_014089
NUP58	hsa-miR-548o-3p	94.2195	NM_014089
NUP58	hsa-miR-3173-5p	94.1068	NM_001008564
NUP58	hsa-miR-6799-3p	94.1068	NM_001008564
NUP58	hsa-miR-4470	93.0842	NM_014089
NUP58	hsa-miR-4649-3p	92.8428	NM_001008564
NUP58	hsa-miR-3692-3p	92.1801	NM_001008564
NUP58	hsa-miR-548g-5p	91.7725	NM_001008564
NUP58	hsa-miR-548f-5p	91.7725	NM_001008564
NUP58	hsa-miR-548x-5p	91.7725	NM_001008564
NUP58	hsa-miR-548aj-5p	91.7725	NM_001008564
NUP58	hsa-miR-3121-3p	90.2195	NM_001008564
NUP58	hsa-miR-5584-5p	89.9431	NM_014089
NUP58	hsa-miR-223-5p	89.7234	NM_014089
NUP58	hsa-miR-5011-5p	89.3352	NM_001008564
NUP58	hsa-miR-7-2-3p	89.1323	NM_001008564
NUP58	hsa-miR-7-1-3p	89.1323	NM_001008564
NUP58	hsa-miR-4261	88.4557	NM_014089
NUP58	hsa-miR-1468-3p	88.1925	NM_001008564
NUP58	hsa-miR-6504-3p	88.0478	NM_014089
NUP58	hsa-miR-520a-5p	87.811	NM_014089
NUP58	hsa-miR-525-5p	87.811	NM_014089
NUP58	hsa-miR-6516-5p	87.7948	NM_014089
NUP58	hsa-let-7a-3p	87.5996	NM_014089
NUP58	hsa-let-7b-3p	87.5996	NM_014089
NUP58	hsa-let-7f-1-3p	87.5996	NM_014089
NUP58	hsa-miR-98-3p	87.5996	NM_014089
NUP58	hsa-miR-6730-3p	87.5077	NM_014089
NUP58	hsa-miR-10395-3p	87.0997	NM_014089
NUP58	hsa-miR-10399-5p	86.6721	NM_014089
NUP58	hsa-miR-892c-5p	86.5674	NM_014089
NUP58	hsa-miR-587	86.0283	NM_014089
NUP58	hsa-miR-4778-5p	85.5559	NM_014089
NUP58	hsa-miR-8084	84.6521	NM_014089
NUP58	hsa-miR-8485	83.8314	NM_001008564
NUP58	hsa-miR-340-5p	83.5692	NM_001008564
NUP58	hsa-miR-330-3p	83.2345	NM_001008564
NUP58	hsa-miR-6768-3p	82.4363	NM_001008564
NUP58	hsa-miR-3142	82.388	NM_014089
NUP58	hsa-miR-4666b	82.3236	NM_001008564
NUP58	hsa-miR-10523-5p	82.1881	NM_014089
NUP58	hsa-miR-1245b-5p	82.0439	NM_014089
NUP58	hsa-miR-874-3p	81.1341	NM_001008564
NUP58	hsa-miR-7976	80.408	NM_001008564
NUP58	hsa-miR-147b-5p	80.2191	NM_014089

Page: 1

Top

Motifs and transcription factors (TFs) regulating NUP58

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NUP58	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NUP58	metacluster_7.13	ZFX (directAnnotation).
NUP58	cisbp__M00968	MTF2 (directAnnotation).
NUP58	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
NUP58	cisbp__M00341	PAX6 (directAnnotation).
NUP58	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NUP58	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
NUP58	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NUP58	cisbp__M00788	ZFY (inferredBy_Orthology).
NUP58	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NUP58	metacluster_175.1	ZNF283 (directAnnotation).
NUP58	hdpi__ZNF304	ZNF304 (directAnnotation).
NUP58	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NUP58	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
NUP58	transfac_pro__M01199	TRIM28 (directAnnotation).
NUP58	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
NUP58	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NUP58	transfac_pro__M03806	ZBTB7C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."