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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NUP210

Summary for NUP210

Gene information	Gene symbol	NUP210
	Ensembl ID	ENSG00000132182
	Entrez ID	23225
	Gene name	nucleoporin 210
	Synonyms	FLJ22389\|GP210\|KIAA0906\|POM210
	Gene type	protein_coding
	UniProtAcc	Q8TEM1

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Dataset with differentially expressed gene: NUP210

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.338233	1.75e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	NK cells	-0.419996	7.07e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.432642	0.00e+00

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Expression of NUP210 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NUP210

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NUP210

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NUP210	hsa-miR-4319	98.2155	NM_024923
NUP210	hsa-miR-125a-5p	97.3486	NM_024923
NUP210	hsa-miR-125b-5p	97.3486	NM_024923
NUP210	hsa-miR-7160-5p	90.564	NM_024923
NUP210	hsa-miR-6069	88.2253	NM_024923
NUP210	hsa-miR-4708-3p	87.4234	NM_024923
NUP210	hsa-miR-223-3p	86.431	NM_024923
NUP210	hsa-miR-766-3p	84.9247	NM_024923
NUP210	hsa-miR-9985	83.981	NM_024923
NUP210	hsa-miR-27b-3p	83.981	NM_024923
NUP210	hsa-miR-27a-3p	83.981	NM_024923
NUP210	hsa-miR-24-3p	83.9094	NM_024923
NUP210	hsa-miR-4477a	82.7254	NM_024923
NUP210	hsa-miR-670-5p	81.3493	NM_024923
NUP210	hsa-miR-488-3p	80.7523	NM_024923

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Motifs and transcription factors (TFs) regulating NUP210

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NUP210	jaspar__MA1483.2	ELF2 (directAnnotation).
NUP210	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
NUP210	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
NUP210	swissregulon__hs__ELF2	ELF2 (directAnnotation).
NUP210	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
NUP210	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
NUP210	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
NUP210	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
NUP210	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
NUP210	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
NUP210	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
NUP210	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
NUP210	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
NUP210	taipale_tf_pairs__FOXO1_SPDEF_WMSCGGATGTKNW_CAP_repr	FOXO1; SPDEF (directAnnotation).
NUP210	metacluster_161.15	NKX3-1 (directAnnotation).
NUP210	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
NUP210	metacluster_26.7	MYNN; MYNN (directAnnotation).
NUP210	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
NUP210	transfac_public__M00266	FOXC2 (inferredBy_Orthology).
NUP210	tfdimers__MD00181	DBP; E2F1 (directAnnotation).
NUP210	taipale_cyt_meth__ZNF250_NTAGGCCTAN_eDBD_meth_repr	ZNF250 (directAnnotation).
NUP210	tfdimers__MD00274	MYCN (directAnnotation).
NUP210	hocomoco__SPDEF_HUMAN.H11MO.0.D	SPDEF (directAnnotation).
NUP210	transfac_pro__M06214	ZNF33B (directAnnotation).
NUP210	taipale_tf_pairs__GCM2_HOXA13_RTRCGGGTAATAAAN_CAP_repr	GCM2; HOXA13 (directAnnotation).
NUP210	metacluster_74.22	HNF1B (directAnnotation).
NUP210	taipale_tf_pairs__POU2F1_FOXO6_RMATATKCNNNNNNNNNNNNNRWMAACA_CAP_repr	FOXO6; POU2F1 (directAnnotation).
NUP210	cisbp__M08190	ZEB1 (directAnnotation).
NUP210	transfac_pro__M06781	ZNF107 (directAnnotation).
NUP210	metacluster_74.7	HNF1B (directAnnotation).
NUP210	metacluster_16.6	SOX1; SOX14; SOX15; SOX18; SOX2; SOX2; SOX8; SRY (directAnnotation). SOX1; SOX10; SOX17; SOX3 (inferredBy_Orthology).
NUP210	flyfactorsurvey__SuH_FlyReg_FBgn0004837	RBPJ (inferredBy_Orthology).
NUP210	transfac_pro__M05452	PRDM13 (directAnnotation).
NUP210	transfac_pro__M06413	ZNF573 (directAnnotation).
NUP210	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATNNNNNATTAN_CAP_repr	ETV5; EVX1 (directAnnotation).
NUP210	transfac_pro__M06224	ZNF415 (directAnnotation).
NUP210	tfdimers__MD00301	E2F6; IKZF1 (directAnnotation).
NUP210	jaspar__MA1154.1	ZNF282 (directAnnotation).
NUP210	metacluster_74.13	HNF1A; HNF1B (directAnnotation).
NUP210	transfac_pro__M05626	ZNF780A (directAnnotation).
NUP210	transfac_pro__M06461	ZNF557 (directAnnotation).
NUP210	transfac_pro__M12556	ETV4 (directAnnotation).
NUP210	transfac_pro__M00678	ETV7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."