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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NUDT12

Summary for NUDT12

Gene information	Gene symbol	NUDT12
	Ensembl ID	ENSG00000112874
	Entrez ID	83594
	Gene name	nudix hydrolase 12
	Synonyms	DKFZP761I172
	Gene type	protein_coding
	UniProtAcc	Q9BQG2

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Dataset with differentially expressed gene: NUDT12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.955176	4.76e-02

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Expression of NUDT12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NUDT12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NUDT12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NUDT12	hsa-miR-548ar-3p	98.756	NM_001300741
NUDT12	hsa-miR-302c-5p	98.356	NM_001300741
NUDT12	hsa-miR-548bc	98.3407	NM_001300741
NUDT12	hsa-miR-548e-3p	98.3407	NM_001300741
NUDT12	hsa-miR-548f-3p	98.3407	NM_001300741
NUDT12	hsa-miR-548a-3p	98.3407	NM_001300741
NUDT12	hsa-miR-548az-3p	98.3407	NM_001300741
NUDT12	hsa-miR-6868-3p	98.2454	NM_001300741
NUDT12	hsa-miR-3143	96.7173	NM_001300741
NUDT12	hsa-miR-3659	95.0759	NM_001300741
NUDT12	hsa-miR-590-3p	94.1199	NM_001300741
NUDT12	hsa-miR-4282	93.4629	NM_001300741
NUDT12	hsa-miR-365a-5p	93.119	NM_001300741
NUDT12	hsa-miR-20a-3p	93.0573	NM_001300741
NUDT12	hsa-miR-365b-5p	91.3141	NM_001300741
NUDT12	hsa-miR-664a-3p	91.2438	NM_001300741
NUDT12	hsa-miR-548c-3p	90.4561	NM_001300741
NUDT12	hsa-miR-4775	89.8617	NM_001300741
NUDT12	hsa-miR-5002-5p	89.6642	NM_001300741
NUDT12	hsa-miR-138-2-3p	89.4504	NM_001300741
NUDT12	hsa-let-7a-3p	88.2738	NM_001300741
NUDT12	hsa-let-7b-3p	88.2738	NM_001300741
NUDT12	hsa-miR-98-3p	88.2738	NM_001300741
NUDT12	hsa-let-7f-1-3p	88.2738	NM_001300741
NUDT12	hsa-miR-5692a	87.539	NM_001300741
NUDT12	hsa-miR-549a-3p	87.1531	NM_001300741
NUDT12	hsa-miR-4649-3p	84.5082	NM_001300741
NUDT12	hsa-miR-6509-5p	84.486	NM_001300741
NUDT12	hsa-miR-4307	83.2075	NM_001300741
NUDT12	hsa-miR-4698	81.9433	NM_001300741
NUDT12	hsa-miR-944	81.865	NM_001300741
NUDT12	hsa-miR-3163	81.1762	NM_001300741
NUDT12	hsa-miR-541-5p	81.1517	NM_001300741
NUDT12	hsa-miR-4750-3p	80.1162	NM_001300741

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Motifs and transcription factors (TFs) regulating NUDT12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NUDT12	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."