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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NTS

Summary for NTS

Gene information	Gene symbol	NTS
	Ensembl ID	ENSG00000133636
	Entrez ID	4922
	Gene name	neurotensin
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NTS

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-1.33577	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.359326	2.67e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-3.18066	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	2.28402	0.00e+00

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Expression of NTS in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NTS

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
NTS	Malignant cells	CPI-SS0A437E174	NTS_SORT1	NTS	SORT1	False	Malignant cells	Endothelial cells	GSE207422_Tor	post	resistant
NTS	Malignant cells	CPI-SS0A437E174	NTS_SORT1	NTS	SORT1	False	Malignant cells	Mono/Macro	GSE207422_Tor	post	resistant
NTS	Malignant cells	CPI-SS0A437E174	NTS_SORT1	NTS	SORT1	False	Malignant cells	Endothelial cells	GSE207422_Tor	post	sensitive
NTS	Malignant cells	CPI-SS0A437E174	NTS_SORT1	NTS	SORT1	False	Malignant cells	Mast cells	GSE207422_Tor	post	sensitive
NTS	Malignant cells	CPI-SS0A437E174	NTS_SORT1	NTS	SORT1	False	Malignant cells	Mono/Macro	GSE207422_Tor	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NTS

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NTS	hsa-miR-377-3p	94.5542	NM_006183
NTS	hsa-miR-4735-5p	93.4905	NM_006183
NTS	hsa-miR-337-3p	92.5031	NM_006183
NTS	hsa-miR-5197-3p	92.4534	NM_006183
NTS	hsa-miR-19b-2-5p	92.2324	NM_006183
NTS	hsa-miR-19a-5p	92.2324	NM_006183
NTS	hsa-miR-19b-1-5p	92.2324	NM_006183
NTS	hsa-miR-4705	91.0714	NM_006183
NTS	hsa-miR-548aw	89.4558	NM_006183
NTS	hsa-miR-4524a-3p	89.2554	NM_006183
NTS	hsa-miR-4760-5p	88.0337	NM_006183
NTS	hsa-miR-570-3p	87.583	NM_006183
NTS	hsa-miR-1262	87.5389	NM_006183
NTS	hsa-miR-4701-3p	87.5389	NM_006183
NTS	hsa-miR-6736-5p	87.5389	NM_006183
NTS	hsa-miR-497-3p	86.3294	NM_006183
NTS	hsa-miR-3145-3p	85.6965	NM_006183
NTS	hsa-miR-8061	85.4349	NM_006183
NTS	hsa-miR-5696	83.9041	NM_006183
NTS	hsa-miR-943	83.8105	NM_006183
NTS	hsa-miR-23c	83.728	NM_006183
NTS	hsa-miR-23a-3p	83.728	NM_006183
NTS	hsa-miR-23b-3p	83.728	NM_006183
NTS	hsa-miR-595	82.4826	NM_006183
NTS	hsa-miR-5692a	81.0064	NM_006183
NTS	hsa-miR-4699-5p	80.8141	NM_006183

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Motifs and transcription factors (TFs) regulating NTS

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NTS	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
NTS	transfac_pro__M05670	ZNF37A (directAnnotation).
NTS	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
NTS	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
NTS	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
NTS	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
NTS	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."