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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NTNG1

Summary for NTNG1

Gene information	Gene symbol	NTNG1
	Ensembl ID	ENSG00000162631
	Entrez ID	22854
	Gene name	netrin G1
	Synonyms	KIAA0976\|Lmnt1
	Gene type	protein_coding
	UniProtAcc	Q9Y2I2

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Dataset with differentially expressed gene: NTNG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	5.16643	3.04e-09

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Expression of NTNG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NTNG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NTNG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NTNG1	hsa-miR-5688	97.4556	NM_001113226
NTNG1	hsa-miR-6878-3p	97.1664	NM_001113226
NTNG1	hsa-miR-495-3p	96.7081	NM_001113226
NTNG1	hsa-miR-135a-5p	94.143	NM_001113226
NTNG1	hsa-miR-135b-5p	94.143	NM_001113226
NTNG1	hsa-miR-4799-5p	93.8609	NM_001113226
NTNG1	hsa-miR-590-3p	93.7523	NM_001113226
NTNG1	hsa-miR-30a-5p	93.1427	NM_001113226
NTNG1	hsa-miR-30d-5p	93.1427	NM_001113226
NTNG1	hsa-miR-30e-5p	93.1427	NM_001113226
NTNG1	hsa-miR-30b-5p	93.1427	NM_001113226
NTNG1	hsa-miR-30c-5p	93.1427	NM_001113226
NTNG1	hsa-miR-3124-3p	93.1416	NM_001312688
NTNG1	hsa-miR-6835-3p	92.8989	NM_001113226
NTNG1	hsa-miR-548az-5p	91.7967	NM_001312688
NTNG1	hsa-miR-9851-5p	91.0277	NM_001113226
NTNG1	hsa-miR-202-5p	90.6054	NM_001312688
NTNG1	hsa-miR-200a-3p	90.2999	NM_001113226
NTNG1	hsa-miR-141-3p	90.2999	NM_001113226
NTNG1	hsa-miR-664b-3p	89.9337	NM_001113226
NTNG1	hsa-miR-579-3p	89.9337	NM_001113226
NTNG1	hsa-miR-5000-5p	89.7491	NM_001312688
NTNG1	hsa-miR-4288	89.4894	NM_001113226
NTNG1	hsa-miR-5004-5p	89.3489	NM_001113226
NTNG1	hsa-miR-548c-3p	89.3428	NM_001113226
NTNG1	hsa-miR-548t-5p	89.0825	NM_001312688
NTNG1	hsa-miR-6804-3p	88.135	NM_001113226
NTNG1	hsa-miR-141-5p	87.5363	NM_001312688
NTNG1	hsa-miR-4422	87.1653	NM_001113226
NTNG1	hsa-miR-1184	87.1611	NM_001113226
NTNG1	hsa-miR-1205	86.378	NM_001113226
NTNG1	hsa-miR-10394-5p	86.378	NM_001113226
NTNG1	hsa-miR-199a-5p	86.0244	NM_001312688
NTNG1	hsa-miR-199b-5p	86.0244	NM_001312688
NTNG1	hsa-miR-6504-3p	85.9202	NM_001113226
NTNG1	hsa-miR-10399-5p	85.9202	NM_001113226
NTNG1	hsa-miR-20a-5p	85.6383	NM_001113226
NTNG1	hsa-miR-106b-5p	85.6383	NM_001113226
NTNG1	hsa-miR-6501-3p	85.3168	NM_001113226
NTNG1	hsa-miR-1231	85.1722	NM_001113226
NTNG1	hsa-miR-6516-5p	85.0739	NM_001312688
NTNG1	hsa-miR-4760-5p	84.8987	NM_001113226
NTNG1	hsa-miR-4495	84.7735	NM_001113226
NTNG1	hsa-miR-212-3p	84.186	NM_001113226
NTNG1	hsa-miR-132-3p	84.186	NM_001113226
NTNG1	hsa-miR-3059-5p	84.1013	NM_001312688
NTNG1	hsa-miR-938	83.6654	NM_001113226
NTNG1	hsa-miR-337-3p	83.2983	NM_001312688
NTNG1	hsa-miR-889-5p	83.0305	NM_001113226
NTNG1	hsa-miR-194-5p	82.9415	NM_001312688

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Motifs and transcription factors (TFs) regulating NTNG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NTNG1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
NTNG1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
NTNG1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NTNG1	transfac_pro__M04617	ZBTB7A (directAnnotation).
NTNG1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NTNG1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
NTNG1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NTNG1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NTNG1	transfac_pro__M07387	ZBTB7A (directAnnotation).
NTNG1	transfac_pro__M07436	WT1 (directAnnotation).
NTNG1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NTNG1	transfac_pro__M00716	ZBTB14 (directAnnotation).
NTNG1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NTNG1	hdpi__HIP2	UBE2K (directAnnotation).
NTNG1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NTNG1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
NTNG1	transfac_pro__M04893	TAF1 (directAnnotation).
NTNG1	transfac_pro__M03876	ZBTB33 (directAnnotation).
NTNG1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NTNG1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NTNG1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
NTNG1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NTNG1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."