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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NT5E

Summary for NT5E

Gene information	Gene symbol	NT5E
	Ensembl ID	ENSG00000135318
	Entrez ID	4907
	Gene name	5'-nucleotidase ecto
	Synonyms	CALJA\|CD73\|eN\|eNT\|NT5
	Gene type	protein_coding
	UniProtAcc	P21589

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Dataset with differentially expressed gene: NT5E

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.09121	6.45e-16
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.413753	1.89e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.518176	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.273141	9.13e-08

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Expression of NT5E in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NT5E

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NT5E

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NT5E	hsa-miR-30a-5p	99.1735	NM_001204813
NT5E	hsa-miR-30d-5p	99.1735	NM_001204813
NT5E	hsa-miR-30c-5p	99.1735	NM_001204813
NT5E	hsa-miR-30e-5p	99.1735	NM_001204813
NT5E	hsa-miR-30b-5p	99.1735	NM_001204813
NT5E	hsa-miR-6856-5p	98.2926	NM_002526
NT5E	hsa-miR-6758-5p	98.2926	NM_002526
NT5E	hsa-miR-10395-5p	97.0282	NM_002526
NT5E	hsa-miR-3134	95.3569	NM_002526
NT5E	hsa-miR-3201	95.2293	NM_002526
NT5E	hsa-miR-4282	94.1025	NM_002526
NT5E	hsa-miR-548an	93.721	NM_002526
NT5E	hsa-miR-4791	92.048	NM_002526
NT5E	hsa-miR-1257	91.728	NM_002526
NT5E	hsa-miR-4496	89.8137	NM_002526
NT5E	hsa-miR-148a-5p	89.4342	NM_002526
NT5E	hsa-miR-193a-3p	88.7745	NM_002526
NT5E	hsa-miR-193b-3p	88.7745	NM_002526
NT5E	hsa-miR-3609	87.6635	NM_002526
NT5E	hsa-miR-548ah-5p	87.6635	NM_002526
NT5E	hsa-miR-377-3p	87.1489	NM_002526
NT5E	hsa-miR-3185	86.5239	NM_002526
NT5E	hsa-miR-3118	86.4642	NM_001204813
NT5E	hsa-miR-134-5p	86.4642	NM_001204813
NT5E	hsa-miR-6515-3p	85.4797	NM_002526
NT5E	hsa-miR-378g	84.5694	NM_002526
NT5E	hsa-miR-5680	84.4651	NM_002526
NT5E	hsa-miR-657	84.1408	NM_002526
NT5E	hsa-miR-12136	83.2397	NM_002526
NT5E	hsa-miR-4534	83.0169	NM_002526
NT5E	hsa-miR-452-3p	82.228	NM_002526
NT5E	hsa-miR-7160-3p	81.3796	NM_002526
NT5E	hsa-miR-1910-3p	80.9551	NM_002526
NT5E	hsa-miR-6511a-5p	80.945	NM_002526
NT5E	hsa-miR-3190-5p	80.6735	NM_002526
NT5E	hsa-miR-203a-5p	80.0271	NM_002526

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Motifs and transcription factors (TFs) regulating NT5E

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NT5E	transfac_pro__M01299	MECP2 (directAnnotation).
NT5E	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
NT5E	transfac_pro__M00716	ZBTB14 (directAnnotation).
NT5E	transfac_pro__M03876	ZBTB33 (directAnnotation).
NT5E	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NT5E	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
NT5E	swissregulon__hs__ETV6	ETV6 (directAnnotation).
NT5E	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
NT5E	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NT5E	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NT5E	jaspar__MA0079.5	SP1 (directAnnotation).
NT5E	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
NT5E	transfac_pro__M04817	ZBTB33 (directAnnotation).
NT5E	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NT5E	"Pentoxifylline"	DB00806	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."