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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NT5C3A

Summary for NT5C3A

Gene information	Gene symbol	NT5C3A
	Ensembl ID	ENSG00000122643
	Entrez ID	51251
	Gene name	5'-nucleotidase, cytosolic IIIA
	Synonyms	cN-III\|hUMP1\|NT5C3\|p36\|P5'N-1\|PN-I\|POMP\|PSN1\|UMPH\|UMPH1
	Gene type	protein_coding
	UniProtAcc	Q9H0P0

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Dataset with differentially expressed gene: NT5C3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.32383	2.65e-06

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Expression of NT5C3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NT5C3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NT5C3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NT5C3A	hsa-miR-5582-3p	93.6451	NM_001002010
NT5C3A	hsa-miR-5094	87.7928	NM_001002009
NT5C3A	hsa-miR-656-3p	86.3062	NM_001002010
NT5C3A	hsa-miR-152-3p	86.0034	NM_001002009
NT5C3A	hsa-miR-148b-3p	86.0034	NM_001002009
NT5C3A	hsa-miR-148a-3p	86.0034	NM_001002009
NT5C3A	hsa-miR-433-5p	83.9651	NM_001002010
NT5C3A	hsa-miR-574-5p	81.8889	NM_001002009
NT5C3A	hsa-miR-2355-5p	81.3948	NM_001002010
NT5C3A	hsa-miR-520f-3p	80.0026	NM_001002009

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Motifs and transcription factors (TFs) regulating NT5C3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NT5C3A	metacluster_141.2	E2F2; E2F3 (directAnnotation).
NT5C3A	cisbp__M02645	ETS1 (directAnnotation).
NT5C3A	metacluster_197.1	E2F2; E2F3; E2F3; E2F4 (directAnnotation).
NT5C3A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
NT5C3A	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
NT5C3A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
NT5C3A	metacluster_52.5	HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2 (directAnnotation).
NT5C3A	transfac_pro__M06267	ZNF805 (directAnnotation).
NT5C3A	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
NT5C3A	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
NT5C3A	metacluster_80.6	ZIC4 (directAnnotation).
NT5C3A	hdpi__SNAPC5	SNAPC5 (directAnnotation).
NT5C3A	jaspar__MA1154.1	ZNF282 (directAnnotation).
NT5C3A	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
NT5C3A	metacluster_164.2	HMBOX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."