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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NSMF

Summary for NSMF

Gene information	Gene symbol	NSMF
	Ensembl ID	ENSG00000165802
	Entrez ID	26012
	Gene name	NMDA receptor synaptonuclear signaling and neuronal migration factor
	Synonyms	NELF
	Gene type	protein_coding
	UniProtAcc	Q6X4W1

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Dataset with differentially expressed gene: NSMF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.266906	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.546462	0.00e+00

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Expression of NSMF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NSMF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NSMF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NSMF	hsa-miR-4325	95.6335	NM_001130969
NSMF	hsa-miR-7976	93.6763	NM_001130969
NSMF	hsa-miR-6887-3p	93.4512	NM_001130969
NSMF	hsa-miR-7703	92.1968	NM_001130969
NSMF	hsa-miR-1207-5p	91.2903	NM_001130969
NSMF	hsa-miR-138-5p	90.8056	NM_001130969
NSMF	hsa-miR-5587-5p	89.5562	NM_001130969
NSMF	hsa-miR-4763-3p	88.5432	NM_001130969
NSMF	hsa-miR-367-3p	88.4698	NM_001130969
NSMF	hsa-miR-32-5p	88.4698	NM_001130969
NSMF	hsa-miR-25-3p	88.4698	NM_001130969
NSMF	hsa-miR-363-3p	88.4698	NM_001130969
NSMF	hsa-miR-92b-3p	88.4698	NM_001130969
NSMF	hsa-miR-92a-3p	88.4698	NM_001130969
NSMF	hsa-miR-3173-5p	88.2319	NM_001130969
NSMF	hsa-miR-6799-3p	88.2319	NM_001130969
NSMF	hsa-miR-4804-3p	85.694	NM_001130970
NSMF	hsa-miR-874-3p	84.367	NM_001130970
NSMF	hsa-miR-15b-5p	83.7099	NM_001130969
NSMF	hsa-miR-16-5p	83.7099	NM_001130969
NSMF	hsa-miR-15a-5p	83.7099	NM_001130969
NSMF	hsa-miR-195-5p	83.7099	NM_001130969
NSMF	hsa-miR-6838-5p	82.6687	NM_001130969
NSMF	hsa-miR-133a-5p	82.4709	NM_001130969
NSMF	hsa-miR-497-5p	81.5068	NM_001130969
NSMF	hsa-miR-424-5p	81.5068	NM_001130969

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Motifs and transcription factors (TFs) regulating NSMF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NSMF	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."