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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NSG1

Summary for NSG1

Gene information	Gene symbol	NSG1
	Ensembl ID	ENSG00000168824
	Entrez ID	27065
	Gene name	neuronal vesicle trafficking associated 1
	Synonyms	D4S234E\|NEEP21\|P21
	Gene type	protein_coding
	UniProtAcc	P42857

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Dataset with differentially expressed gene: NSG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.466411	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.785066	0.00e+00

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Expression of NSG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NSG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NSG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NSG1	hsa-miR-500a-3p	95.5187	NM_001040101
NSG1	hsa-miR-524-5p	95.2809	NM_001040101
NSG1	hsa-miR-520d-5p	95.2809	NM_001040101
NSG1	hsa-miR-2114-5p	95.108	NM_001040101
NSG1	hsa-miR-3941	94.98	NM_001040101
NSG1	hsa-miR-376b-3p	92.2304	NM_001040101
NSG1	hsa-miR-376a-3p	92.2304	NM_001040101
NSG1	hsa-miR-199b-5p	91.653	NM_001040101
NSG1	hsa-miR-199a-5p	91.653	NM_001040101
NSG1	hsa-miR-1825	91.4861	NM_001040101
NSG1	hsa-miR-4743-3p	90.0478	NM_001040101
NSG1	hsa-miR-4672	88.8206	NM_001040101
NSG1	hsa-miR-6794-3p	87.6933	NM_001040101
NSG1	hsa-miR-466	87.2042	NM_001040101
NSG1	hsa-miR-627-3p	86.6073	NM_001040101
NSG1	hsa-miR-1252-3p	85.2051	NM_001040101
NSG1	hsa-miR-137-3p	85.047	NM_001040101
NSG1	hsa-miR-12123	84.9088	NM_001040101
NSG1	hsa-miR-518a-5p	84.7273	NM_001040101
NSG1	hsa-miR-527	84.7273	NM_001040101
NSG1	hsa-miR-4666a-5p	84.4528	NM_001040101
NSG1	hsa-miR-6838-5p	83.8578	NM_001040101
NSG1	hsa-miR-15a-5p	83.8578	NM_001040101
NSG1	hsa-miR-195-5p	83.8578	NM_001040101
NSG1	hsa-miR-424-5p	83.8578	NM_001040101
NSG1	hsa-miR-497-5p	83.8578	NM_001040101
NSG1	hsa-miR-15b-5p	83.8578	NM_001040101
NSG1	hsa-miR-16-5p	83.8578	NM_001040101
NSG1	hsa-miR-1293	83.8052	NM_001040101
NSG1	hsa-miR-4483	83.3963	NM_001040101
NSG1	hsa-miR-103a-3p	82.9201	NM_001040101
NSG1	hsa-miR-107	82.9201	NM_001040101
NSG1	hsa-miR-203a-3p	82.7066	NM_001040101
NSG1	hsa-miR-600	81.3609	NM_001040101
NSG1	hsa-miR-30e-5p	81.2848	NM_001040101
NSG1	hsa-miR-30a-5p	81.2848	NM_001040101
NSG1	hsa-miR-30d-5p	81.2848	NM_001040101
NSG1	hsa-miR-30c-5p	81.2848	NM_001040101
NSG1	hsa-miR-30b-5p	81.2848	NM_001040101
NSG1	hsa-miR-889-3p	81.157	NM_001040101

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Motifs and transcription factors (TFs) regulating NSG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NSG1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NSG1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
NSG1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
NSG1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
NSG1	jaspar__MA0079.5	SP1 (directAnnotation).
NSG1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NSG1	transfac_pro__M07397	ZNF148 (directAnnotation).
NSG1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NSG1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NSG1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NSG1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NSG1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NSG1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NSG1	transfac_pro__M01175	ZBTB7B (directAnnotation).
NSG1	tfdimers__MD00151	CHURC1 (directAnnotation).
NSG1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NSG1	transfac_pro__M01303	SP1 (directAnnotation).
NSG1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NSG1	transfac_pro__M01714	KLF15 (directAnnotation).
NSG1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NSG1	transfac_pro__M02089	E2F3 (directAnnotation).
NSG1	metacluster_3.14	WT1; WT1 (directAnnotation).
NSG1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NSG1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NSG1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NSG1	cisbp__M07938	E2F1 (directAnnotation).
NSG1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
NSG1	transfac_pro__M07436	WT1 (directAnnotation).
NSG1	transfac_pro__M02281	SP1 (directAnnotation).
NSG1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NSG1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."