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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NSD3

Summary for NSD3

Gene information	Gene symbol	NSD3
	Ensembl ID	ENSG00000147548
	Entrez ID	54904
	Gene name	nuclear receptor binding SET domain protein 3
	Synonyms	FLJ20353\|KMT3F\|WHISTLE\|WHSC1L1
	Gene type	protein_coding
	UniProtAcc	Q9BZ95

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Dataset with differentially expressed gene: NSD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.277854	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.276855	5.61e-04
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.264199	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.338611	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.260796	9.27e-40
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.451463	0.00e+00

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Expression of NSD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NSD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NSD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NSD3	hsa-miR-3679-3p	99.2007	NM_017778
NSD3	hsa-miR-450b-5p	93.0574	NM_017778
NSD3	hsa-miR-6885-3p	92.5989	NM_023034
NSD3	hsa-miR-454-3p	92.3786	NM_017778
NSD3	hsa-miR-508-3p	92.3753	NM_017778
NSD3	hsa-miR-580-5p	91.8428	NM_017778
NSD3	hsa-miR-6864-5p	90.4375	NM_023034
NSD3	hsa-miR-4677-5p	89.5039	NM_023034
NSD3	hsa-miR-130b-3p	89.2796	NM_017778
NSD3	hsa-miR-301b-3p	89.2796	NM_017778
NSD3	hsa-miR-3666	89.2796	NM_017778
NSD3	hsa-miR-130a-3p	89.2796	NM_017778
NSD3	hsa-miR-4295	89.2796	NM_017778
NSD3	hsa-miR-301a-3p	89.2796	NM_017778
NSD3	hsa-miR-6808-3p	88.8419	NM_017778
NSD3	hsa-miR-6884-3p	88.0475	NM_017778
NSD3	hsa-miR-943	87.1128	NM_017778
NSD3	hsa-miR-3146	87.0972	NM_017778
NSD3	hsa-miR-5187-5p	86.6719	NM_017778
NSD3	hsa-miR-6757-5p	86.2652	NM_017778
NSD3	hsa-miR-7515	85.7608	NM_023034
NSD3	hsa-miR-8485	85.4967	NM_023034
NSD3	hsa-miR-192-3p	85.0516	NM_017778
NSD3	hsa-miR-2116-5p	84.1454	NM_023034
NSD3	hsa-miR-125b-2-3p	81.2265	NM_017778
NSD3	hsa-miR-4797-3p	80.901	NM_023034
NSD3	hsa-miR-4504	80.5644	NM_017778
NSD3	hsa-miR-548c-3p	80.2072	NM_017778

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Motifs and transcription factors (TFs) regulating NSD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."