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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NSD1

Summary for NSD1

Gene information	Gene symbol	NSD1
	Ensembl ID	ENSG00000165671
	Entrez ID	64324
	Gene name	nuclear receptor binding SET domain protein 1
	Synonyms	ARA267\|FLJ22263\|KMT3B\|STO
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NSD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.652537	1.41e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.263685	0.00e+00

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Expression of NSD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NSD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NSD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NSD1	hsa-miR-29b-3p	98.5647	NM_022455
NSD1	hsa-miR-29c-3p	98.5647	NM_022455
NSD1	hsa-miR-29a-3p	98.5647	NM_022455
NSD1	hsa-miR-8485	98.2281	NM_022455
NSD1	hsa-miR-6124	98.1321	NM_022455
NSD1	hsa-miR-3915	97.5422	NM_022455
NSD1	hsa-miR-3659	96.5512	NM_022455
NSD1	hsa-miR-101-3p	95.3845	NM_022455
NSD1	hsa-miR-3605-5p	95.1274	NM_022455
NSD1	hsa-miR-5682	94.9256	NM_022455
NSD1	hsa-miR-3120-5p	94.5433	NM_022455
NSD1	hsa-miR-6739-5p	94.4829	NM_022455
NSD1	hsa-miR-1236-3p	93.6181	NM_022455
NSD1	hsa-miR-548e-5p	93.3619	NM_022455
NSD1	hsa-miR-6733-5p	92.4201	NM_022455
NSD1	hsa-miR-486-3p	92.4027	NM_022455
NSD1	hsa-miR-3681-3p	90.8175	NM_022455
NSD1	hsa-miR-7976	90.583	NM_022455
NSD1	hsa-miR-4291	89.9241	NM_022455
NSD1	hsa-miR-216a-3p	89.8289	NM_022455
NSD1	hsa-miR-128-3p	89.8289	NM_022455
NSD1	hsa-miR-34a-3p	89.4463	NM_022455
NSD1	hsa-miR-625-5p	89.3341	NM_022455
NSD1	hsa-miR-194-3p	88.8148	NM_022455
NSD1	hsa-miR-6871-3p	88.7931	NM_022455
NSD1	hsa-miR-27a-3p	88.4776	NM_022455
NSD1	hsa-miR-9985	88.4776	NM_022455
NSD1	hsa-miR-27b-3p	88.4776	NM_022455
NSD1	hsa-miR-4425	88.3971	NM_022455
NSD1	hsa-miR-186-5p	88.1129	NM_022455
NSD1	hsa-miR-450a-1-3p	88.1021	NM_022455
NSD1	hsa-miR-6790-5p	87.8262	NM_022455
NSD1	hsa-miR-4658	87.8262	NM_022455
NSD1	hsa-miR-6749-3p	87.2654	NM_022455
NSD1	hsa-miR-3153	87.2523	NM_022455
NSD1	hsa-miR-6758-5p	86.8362	NM_022455
NSD1	hsa-miR-4487	86.7159	NM_022455
NSD1	hsa-miR-5584-5p	86.2917	NM_022455
NSD1	hsa-miR-342-3p	86.1795	NM_022455
NSD1	hsa-miR-922	86.149	NM_022455
NSD1	hsa-miR-6513-5p	85.857	NM_022455
NSD1	hsa-miR-3619-5p	85.7086	NM_022455
NSD1	hsa-miR-6893-5p	85.176	NM_022455
NSD1	hsa-miR-6808-5p	85.176	NM_022455
NSD1	hsa-miR-940	84.9916	NM_022455
NSD1	hsa-miR-761	84.7932	NM_022455
NSD1	hsa-miR-214-3p	84.7932	NM_022455
NSD1	hsa-miR-6856-5p	83.5843	NM_022455
NSD1	hsa-miR-4667-3p	83.558	NM_022455
NSD1	hsa-miR-1275	83.3783	NM_022455

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Motifs and transcription factors (TFs) regulating NSD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NSD1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
NSD1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
NSD1	metacluster_141.4	GLIS2 (directAnnotation).
NSD1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
NSD1	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
NSD1	metacluster_182.10	ZFX (directAnnotation).
NSD1	transfac_public__M00024	E2F1 (directAnnotation).
NSD1	transfac_pro__M07483	CXXC1 (directAnnotation).
NSD1	taipale_tf_pairs__ETV2_EOMES_NGGTGTNNNNNNNNNNNNNNNCCGGAWNNN_CAP_repr	EOMES; ETV2 (directAnnotation).
NSD1	transfac_pro__M05838	ZNF550 (directAnnotation).
NSD1	transfac_pro__M05523	ZBTB46 (directAnnotation).
NSD1	transfac_pro__M06622	ZNF681 (directAnnotation).
NSD1	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
NSD1	transfac_pro__M06594	ZNF668 (directAnnotation).
NSD1	transfac_pro__M06111	ZNF254 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."