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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NRXN1

Summary for NRXN1

Gene information	Gene symbol	NRXN1
	Ensembl ID	ENSG00000179915
	Entrez ID	9378
	Gene name	neurexin 1
	Synonyms	Hs.22998\|KIAA0578
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NRXN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.410188	0.00e+00

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Expression of NRXN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRXN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRXN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRXN1	hsa-miR-6867-5p	100	NM_138735
NRXN1	hsa-miR-9902	99.891	NM_001135659
NRXN1	hsa-miR-5010-3p	99.8345	NM_001135659
NRXN1	hsa-miR-3688-5p	99.1221	NM_138735
NRXN1	hsa-miR-5688	98.8749	NM_001135659
NRXN1	hsa-miR-9983-3p	98.8693	NM_138735
NRXN1	hsa-miR-3613-3p	98.6097	NM_001135659
NRXN1	hsa-miR-495-3p	98.3253	NM_001135659
NRXN1	hsa-miR-129-5p	98.1551	NM_138735
NRXN1	hsa-miR-1261	97.764	NM_138735
NRXN1	hsa-miR-1284	97.1762	NM_138735
NRXN1	hsa-miR-3154	96.8327	NM_001135659
NRXN1	hsa-miR-335-5p	96.3124	NM_001135659
NRXN1	hsa-miR-1290	96.2139	NM_138735
NRXN1	hsa-miR-6818-5p	95.8576	NM_001135659
NRXN1	hsa-miR-4718	95.8481	NM_001135659
NRXN1	hsa-miR-599	95.846	NM_001135659
NRXN1	hsa-miR-4482-3p	95.8323	NM_138735
NRXN1	hsa-miR-636	95.4231	NM_001135659
NRXN1	hsa-miR-654-3p	95.3811	NM_138735
NRXN1	hsa-miR-6740-3p	95.1517	NM_001135659
NRXN1	hsa-miR-5011-5p	94.6088	NM_138735
NRXN1	hsa-miR-23b-3p	94.479	NM_138735
NRXN1	hsa-miR-23a-3p	94.479	NM_138735
NRXN1	hsa-miR-23c	94.479	NM_138735
NRXN1	hsa-miR-3658	94.049	NM_001135659
NRXN1	hsa-miR-380-3p	93.894	NM_138735
NRXN1	hsa-miR-4330	93.8423	NM_138735
NRXN1	hsa-miR-196a-3p	93.7237	NM_001135659
NRXN1	hsa-miR-4319	93.5168	NM_001135659
NRXN1	hsa-miR-3680-3p	93.387	NM_001135659
NRXN1	hsa-miR-9-3p	93.1958	NM_001135659
NRXN1	hsa-miR-377-3p	93.1425	NM_001135659
NRXN1	hsa-miR-577	92.8653	NM_138735
NRXN1	hsa-miR-4802-3p	92.833	NM_138735
NRXN1	hsa-miR-4438	92.2573	NM_001135659
NRXN1	hsa-miR-656-3p	92.2309	NM_138735
NRXN1	hsa-miR-3691-5p	92.0808	NM_138735
NRXN1	hsa-miR-12136	91.9452	NM_138735
NRXN1	hsa-miR-7-1-3p	91.8528	NM_001135659
NRXN1	hsa-miR-7-2-3p	91.8528	NM_001135659
NRXN1	hsa-miR-942-5p	91.8078	NM_001135659
NRXN1	hsa-miR-3119	91.6803	NM_001135659
NRXN1	hsa-miR-19b-2-5p	91.6162	NM_138735
NRXN1	hsa-miR-19b-1-5p	91.6162	NM_138735
NRXN1	hsa-miR-125b-5p	91.2707	NM_001135659
NRXN1	hsa-miR-125a-5p	91.2707	NM_001135659
NRXN1	hsa-miR-2052	90.9049	NM_138735
NRXN1	hsa-miR-5582-3p	90.8473	NM_001135659
NRXN1	hsa-miR-485-3p	90.7282	NM_001135659

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Motifs and transcription factors (TFs) regulating NRXN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRXN1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NRXN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NRXN1	transfac_pro__M07397	ZNF148 (directAnnotation).
NRXN1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NRXN1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NRXN1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NRXN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NRXN1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NRXN1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NRXN1	transfac_pro__M01175	ZBTB7B (directAnnotation).
NRXN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NRXN1	tfdimers__MD00151	CHURC1 (directAnnotation).
NRXN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NRXN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NRXN1	transfac_pro__M01303	SP1 (directAnnotation).
NRXN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NRXN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NRXN1	transfac_pro__M02090	E2F4 (directAnnotation).
NRXN1	transfac_pro__M01714	KLF15 (directAnnotation).
NRXN1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NRXN1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NRXN1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NRXN1	transfac_pro__M02089	E2F3 (directAnnotation).
NRXN1	metacluster_3.14	WT1; WT1 (directAnnotation).
NRXN1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NRXN1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NRXN1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NRXN1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NRXN1	cisbp__M07938	E2F1 (directAnnotation).
NRXN1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NRXN1	transfac_pro__M07436	WT1 (directAnnotation).
NRXN1	transfac_pro__M02281	SP1 (directAnnotation).
NRXN1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NRXN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NRXN1	transfac_pro__M02898	SMAD3 (directAnnotation).
NRXN1	transfac_public__M00491	PATZ1 (directAnnotation).
NRXN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NRXN1	"Calcium citrate"	DB11093	small molecule
NRXN1	"Calcium phosphate dihydrate"	DB14481	small molecule
NRXN1	"Calcium Phosphate"	DB11348	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."