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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NRP2

Summary for NRP2

Gene information	Gene symbol	NRP2
	Ensembl ID	ENSG00000118257
	Entrez ID	8828
	Gene name	neuropilin 2
	Synonyms	VEGF165R2
	Gene type	protein_coding
	UniProtAcc	O60462

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Dataset with differentially expressed gene: NRP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.266734	4.86e-22
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.611086	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.365102	0.00e+00

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Expression of NRP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRP2	hsa-miR-331-3p	98.761	NM_003872
NRP2	hsa-miR-92a-1-5p	97.0916	NM_018534
NRP2	hsa-miR-33a-3p	95.7947	NM_201266
NRP2	hsa-miR-578	95.3752	NM_018534
NRP2	hsa-miR-24-3p	93.6918	NM_003872
NRP2	hsa-miR-605-5p	93.5113	NM_003872
NRP2	hsa-miR-3148	93.3116	NM_201266
NRP2	hsa-miR-107	93.1856	NM_018534
NRP2	hsa-miR-103a-3p	93.1856	NM_018534
NRP2	hsa-miR-651-3p	92.742	NM_201266
NRP2	hsa-miR-8083	92.5707	NM_003872
NRP2	hsa-miR-3065-5p	92.4752	NM_018534
NRP2	hsa-miR-6810-3p	92.4285	NM_003872
NRP2	hsa-miR-6824-3p	92.2024	NM_201266
NRP2	hsa-miR-6764-3p	92.2024	NM_201266
NRP2	hsa-miR-377-3p	92.1694	NM_018534
NRP2	hsa-let-7f-1-3p	92.0088	NM_201266
NRP2	hsa-miR-98-3p	92.0088	NM_201266
NRP2	hsa-let-7b-3p	92.0088	NM_201266
NRP2	hsa-let-7a-3p	92.0088	NM_201266
NRP2	hsa-miR-6801-3p	91.229	NM_003872
NRP2	hsa-miR-587	91.1987	NM_003872
NRP2	hsa-miR-9985	91.1048	NM_003872
NRP2	hsa-miR-8485	89.2651	NM_018534
NRP2	hsa-miR-876-5p	89.0115	NM_201264
NRP2	hsa-miR-15a-5p	88.2589	NM_003872
NRP2	hsa-miR-15b-5p	88.2589	NM_003872
NRP2	hsa-miR-27a-3p	88.2475	NM_003872
NRP2	hsa-miR-27b-3p	88.2475	NM_003872
NRP2	hsa-miR-4774-5p	88.2362	NM_201266
NRP2	hsa-miR-545-3p	86.1016	NM_003872
NRP2	hsa-miR-144-3p	85.709	NM_018534
NRP2	hsa-miR-7847-3p	85.2875	NM_003872
NRP2	hsa-miR-4308	85.0814	NM_003872
NRP2	hsa-miR-149-5p	84.09	NM_003872
NRP2	hsa-miR-6778-3p	83.8323	NM_201266
NRP2	hsa-miR-6781-3p	83.7143	NM_003872
NRP2	hsa-miR-3167	83.517	NM_201264
NRP2	hsa-miR-16-5p	83.4943	NM_003872
NRP2	hsa-miR-195-5p	83.4943	NM_003872
NRP2	hsa-miR-6838-5p	83.4943	NM_003872
NRP2	hsa-miR-6750-3p	83.0831	NM_003872
NRP2	hsa-miR-10522-5p	82.7853	NM_201266
NRP2	hsa-miR-4307	82.6251	NM_201266
NRP2	hsa-miR-345-3p	82.4931	NM_201266
NRP2	hsa-miR-3169	82.3679	NM_003872
NRP2	hsa-miR-1256	82.2661	NM_003872
NRP2	hsa-miR-362-3p	82.2102	NM_003872
NRP2	hsa-miR-329-3p	82.2102	NM_003872
NRP2	hsa-miR-519a-3p	82.1312	NM_018534

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Motifs and transcription factors (TFs) regulating NRP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRP2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NRP2	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
NRP2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
NRP2	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
NRP2	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
NRP2	metacluster_22.13	MAFK (inferredBy_Orthology).
NRP2	transfac_pro__M05612	ZNF189 (directAnnotation).
NRP2	transfac_pro__M05418	ZNF521 (directAnnotation).
NRP2	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NRP2	"ATYR1923"	DB16453	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."