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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NRG1

Summary for NRG1

Gene information	Gene symbol	NRG1
	Ensembl ID	ENSG00000157168
	Entrez ID	3084
	Gene name	neuregulin 1
	Synonyms	GGF\|HGL\|HRG\|NDF\|NRG1-IT2
	Gene type	protein_coding
	UniProtAcc	Q02297

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Dataset with differentially expressed gene: NRG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.451772	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.521023	1.00e-37
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.447465	3.51e-36
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.504172	6.94e-36

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Expression of NRG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRG1	hsa-miR-3163	99.1852	NM_001322206
NRG1	hsa-miR-6875-3p	98.4957	NM_001322206
NRG1	hsa-miR-137-3p	94.8745	NM_001322206
NRG1	hsa-miR-4645-3p	94.2917	NM_001322206
NRG1	hsa-miR-3920	93.9032	NM_001322205
NRG1	hsa-miR-5187-3p	93.2281	NM_013958
NRG1	hsa-miR-4699-3p	92.4392	NM_001322206
NRG1	hsa-miR-6830-3p	91.9375	NM_001322205
NRG1	hsa-miR-4666b	91.6389	NM_001322205
NRG1	hsa-miR-10527-5p	91.6176	NM_001322206
NRG1	hsa-miR-758-3p	91.5719	NM_013958
NRG1	hsa-miR-5692a	91.4823	NM_001322206
NRG1	hsa-miR-4318	91.1067	NM_001322205
NRG1	hsa-miR-4778-3p	90.3097	NM_001322206
NRG1	hsa-miR-196a-1-3p	90.0301	NM_001160002
NRG1	hsa-miR-4504	89.9567	NM_013958
NRG1	hsa-miR-374c-5p	89.6321	NM_001322205
NRG1	hsa-miR-655-3p	89.6321	NM_001322205
NRG1	hsa-miR-6516-5p	88.8163	NM_001322206
NRG1	hsa-miR-222-5p	88.7908	NM_013958
NRG1	hsa-miR-4639-3p	87.8652	NM_001322206
NRG1	hsa-miR-485-3p	87.5294	NM_001160002
NRG1	hsa-miR-539-3p	87.5294	NM_001160002
NRG1	hsa-miR-95-5p	87.5045	NM_013958
NRG1	hsa-miR-4662a-3p	87.1997	NM_001322205
NRG1	hsa-miR-936	87.1087	NM_013958
NRG1	hsa-miR-126-5p	86.9278	NM_001322205
NRG1	hsa-miR-568	86.8628	NM_013958
NRG1	hsa-miR-4775	86.4857	NM_001322206
NRG1	hsa-miR-4540	86.428	NM_001322206
NRG1	hsa-miR-4272	86.0268	NM_001160002
NRG1	hsa-miR-183-5p	85.5908	NM_001322205
NRG1	hsa-miR-452-3p	85.4938	NM_001160002
NRG1	hsa-miR-4659b-3p	84.6432	NM_001159996
NRG1	hsa-miR-4659a-3p	84.6432	NM_001159996
NRG1	hsa-miR-3140-3p	84.1954	NM_013958
NRG1	hsa-miR-302a-5p	84.178	NM_001322205
NRG1	hsa-miR-3192-5p	84.0922	NM_001322206
NRG1	hsa-miR-6870-5p	83.894	NM_001159996
NRG1	hsa-miR-1228-3p	83.4902	NM_013958
NRG1	hsa-miR-25-3p	83.3703	NM_001322206
NRG1	hsa-miR-7108-5p	83.1754	NM_001322206
NRG1	hsa-miR-92b-3p	82.0835	NM_001322206
NRG1	hsa-miR-92a-3p	82.0835	NM_001322206
NRG1	hsa-miR-32-5p	82.0835	NM_001322206
NRG1	hsa-miR-12123	82.0055	NM_001160002
NRG1	hsa-miR-4666a-3p	81.6492	NM_001322205
NRG1	hsa-miR-4448	81.4761	NM_001322206
NRG1	hsa-miR-4999-5p	81.4495	NM_001322205
NRG1	hsa-miR-500a-3p	81.3885	NM_001322206

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Motifs and transcription factors (TFs) regulating NRG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRG1	transfac_pro__M04826	EP300 (directAnnotation).
NRG1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
NRG1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
NRG1	hdpi__ETV4	ETV4 (directAnnotation).
NRG1	hdpi__TP73	TP73 (directAnnotation).
NRG1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
NRG1	cisbp__M02645	ETS1 (directAnnotation).
NRG1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
NRG1	jaspar__MA1708.1	ETV7 (directAnnotation).
NRG1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
NRG1	hdpi__ELF2	ELF2 (directAnnotation).
NRG1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
NRG1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
NRG1	metacluster_183.4	ETS1 (inferredBy_Orthology).
NRG1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
NRG1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
NRG1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
NRG1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NRG1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NRG1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
NRG1	transfac_pro__M04862	NRF1 (directAnnotation).
NRG1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NRG1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
NRG1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
NRG1	metacluster_81.7	CREB1 (directAnnotation).
NRG1	cisbp__M08198	ELF1 (directAnnotation).
NRG1	transfac_pro__M00492	STAT1 (directAnnotation).
NRG1	transfac_pro__M04848	TAF1 (directAnnotation).
NRG1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
NRG1	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
NRG1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NRG1	jaspar__MA0502.2	NFYB (directAnnotation).
NRG1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
NRG1	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
NRG1	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."