Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NREP

Summary for NREP

Gene information	Gene symbol	NREP
	Ensembl ID	ENSG00000134986
	Entrez ID	9315
	Gene name	neuronal regeneration related protein
	Synonyms	C5orf13\|D4S114\|P311\|PRO1873\|PTZ17\|SEZ17
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: NREP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.38669	2.50e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Progenitors	0.534974	9.95e-04
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.710118	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.263263	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.291555	1.88e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.387612	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.455945	4.35e-30
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.385418	1.66e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.579795	1.79e-39

Top

Expression of NREP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NREP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NREP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NREP	hsa-miR-4672	99.2377	NM_004772
NREP	hsa-miR-6077	97.8054	NM_004772
NREP	hsa-miR-7-5p	96.1944	NM_004772
NREP	hsa-miR-190b-3p	95.2346	NM_004772
NREP	hsa-miR-3646	94.5362	NM_004772
NREP	hsa-miR-3190-3p	92.8548	NM_004772
NREP	hsa-miR-605-5p	92.8306	NM_001142477
NREP	hsa-miR-5702	92.1645	NM_001142477
NREP	hsa-miR-582-5p	92.0966	NM_004772
NREP	hsa-miR-6768-5p	92.0885	NM_004772
NREP	hsa-miR-4261	91.4417	NM_004772
NREP	hsa-miR-596	90.3265	NM_004772
NREP	hsa-miR-3941	90.206	NM_004772
NREP	hsa-miR-128-3p	90.1719	NM_004772
NREP	hsa-miR-216a-3p	90.1719	NM_004772
NREP	hsa-miR-4802-3p	89.9312	NM_001142477
NREP	hsa-miR-5588-3p	88.9918	NM_004772
NREP	hsa-miR-4302	88.5468	NM_004772
NREP	hsa-miR-147b-5p	88.4992	NM_004772
NREP	hsa-miR-132-3p	88.0561	NM_004772
NREP	hsa-miR-212-3p	88.0561	NM_004772
NREP	hsa-miR-466	87.7437	NM_004772
NREP	hsa-miR-3681-3p	86.8125	NM_004772
NREP	hsa-miR-4303	86.5105	NM_001142477
NREP	hsa-miR-6733-3p	86.4942	NM_001142477
NREP	hsa-miR-29c-3p	86.3704	NM_001142477
NREP	hsa-miR-29a-3p	86.3704	NM_001142477
NREP	hsa-miR-29b-3p	86.3704	NM_001142477
NREP	hsa-miR-4496	86.337	NM_004772
NREP	hsa-miR-137-3p	86.2347	NM_004772
NREP	hsa-miR-3194-3p	86.0201	NM_004772
NREP	hsa-miR-6833-5p	85.3761	NM_004772
NREP	hsa-miR-8080	83.9341	NM_004772
NREP	hsa-miR-1284	81.7634	NM_001142477
NREP	hsa-miR-27b-3p	81.5485	NM_001142477
NREP	hsa-miR-9985	81.5485	NM_001142477
NREP	hsa-miR-27a-3p	81.5485	NM_001142477
NREP	hsa-miR-4779	81.1938	NM_004772
NREP	hsa-miR-380-3p	80.9667	NM_001142477
NREP	hsa-miR-4493	80.5386	NM_004772
NREP	hsa-miR-541-3p	80.2207	NM_004772
NREP	hsa-miR-654-5p	80.2207	NM_004772

Page: 1

Top

Motifs and transcription factors (TFs) regulating NREP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NREP	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NREP	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NREP	transfac_pro__M04950	EGR1 (directAnnotation).
NREP	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NREP	cisbp__M08198	ELF1 (directAnnotation).
NREP	transfac_pro__M00652	NRF1 (directAnnotation).
NREP	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NREP	transfac_pro__M04866	HDAC2 (directAnnotation).
NREP	jaspar__MA1122.1	TFDP1 (directAnnotation).
NREP	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
NREP	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
NREP	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
NREP	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NREP	transfac_pro__M04617	ZBTB7A (directAnnotation).
NREP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NREP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NREP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NREP	transfac_pro__M07387	ZBTB7A (directAnnotation).
NREP	transfac_pro__M07436	WT1 (directAnnotation).
NREP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NREP	transfac_pro__M00716	ZBTB14 (directAnnotation).
NREP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NREP	hdpi__HIP2	UBE2K (directAnnotation).
NREP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NREP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
NREP	transfac_pro__M04893	TAF1 (directAnnotation).
NREP	transfac_pro__M03876	ZBTB33 (directAnnotation).
NREP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NREP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NREP	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
NREP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NREP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NREP	swissregulon__hs__ELF2	ELF2 (directAnnotation).
NREP	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
NREP	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
NREP	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
NREP	transfac_pro__M04826	EP300 (directAnnotation).
NREP	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
NREP	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
NREP	transfac_pro__M05817	ZNF546 (directAnnotation).
NREP	jaspar__MA1483.2	ELF2 (directAnnotation).
NREP	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
NREP	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
NREP	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
NREP	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
NREP	metacluster_55.5	ZNF541 (directAnnotation).
NREP	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
NREP	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
NREP	transfac_pro__M06032	ZNF727 (directAnnotation).
NREP	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."