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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NRBF2

Summary for NRBF2

Gene information	Gene symbol	NRBF2
	Ensembl ID	ENSG00000148572
	Entrez ID	29982
	Gene name	nuclear receptor binding factor 2
	Synonyms	COPR1\|COPR2\|DKFZp564C1664\|FLJ30395
	Gene type	protein_coding
	UniProtAcc	Q96F24

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Dataset with differentially expressed gene: NRBF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.291965	1.40e-30
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.302994	1.23e-15
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.502042	1.70e-29

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Expression of NRBF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRBF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRBF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRBF2	hsa-miR-607	97.6893	NM_001282405
NRBF2	hsa-miR-6732-3p	96.71	NM_001282405
NRBF2	hsa-miR-891a-3p	95.6256	NM_001282405
NRBF2	hsa-miR-3620-3p	95.4117	NM_001282405
NRBF2	hsa-miR-659-3p	94.8776	NM_001282405
NRBF2	hsa-miR-3920	94.473	NM_001282405
NRBF2	hsa-miR-655-5p	93.6234	NM_001282405
NRBF2	hsa-miR-582-3p	93.3367	NM_001282405
NRBF2	hsa-miR-4495	92.4641	NM_001282405
NRBF2	hsa-miR-6832-3p	92.2425	NM_001282405
NRBF2	hsa-miR-644a	92.1185	NM_001282405
NRBF2	hsa-miR-362-3p	92.0066	NM_001282405
NRBF2	hsa-miR-329-3p	92.0066	NM_001282405
NRBF2	hsa-miR-652-5p	91.7687	NM_001282405
NRBF2	hsa-miR-4422	91.6772	NM_001282405
NRBF2	hsa-miR-218-1-3p	90.9873	NM_001282405
NRBF2	hsa-miR-216a-3p	90.7274	NM_001282405
NRBF2	hsa-miR-128-3p	90.7274	NM_001282405
NRBF2	hsa-miR-495-3p	90.5516	NM_001282405
NRBF2	hsa-miR-5700	90.1319	NM_001282405
NRBF2	hsa-miR-9985	89.8291	NM_001282405
NRBF2	hsa-miR-27a-3p	89.8291	NM_001282405
NRBF2	hsa-miR-27b-3p	89.8291	NM_001282405
NRBF2	hsa-miR-5006-3p	88.5089	NM_001282405
NRBF2	hsa-miR-4755-5p	88.5089	NM_001282405
NRBF2	hsa-miR-3924	88.5058	NM_001282405
NRBF2	hsa-miR-345-3p	88.0811	NM_001282405
NRBF2	hsa-miR-5688	87.5697	NM_001282405
NRBF2	hsa-miR-3688-5p	87.1845	NM_001282405
NRBF2	hsa-miR-3681-3p	86.97	NM_001282405
NRBF2	hsa-miR-4528	86.7737	NM_001282405
NRBF2	hsa-miR-204-5p	86.6452	NM_001282405
NRBF2	hsa-miR-211-5p	86.6452	NM_001282405
NRBF2	hsa-let-7b-3p	86.1227	NM_001282405
NRBF2	hsa-miR-98-3p	86.1227	NM_001282405
NRBF2	hsa-let-7a-3p	86.1227	NM_001282405
NRBF2	hsa-let-7f-1-3p	86.1227	NM_001282405
NRBF2	hsa-miR-5087	85.6766	NM_001282405
NRBF2	hsa-miR-8074	85.6592	NM_001282405
NRBF2	hsa-miR-454-3p	85.6392	NM_001282405
NRBF2	hsa-miR-3059-5p	85.3874	NM_001282405
NRBF2	hsa-miR-4446-5p	85.3823	NM_001282405
NRBF2	hsa-miR-3941	84.5683	NM_001282405
NRBF2	hsa-miR-548g-3p	84.5067	NM_001282405
NRBF2	hsa-miR-548av-3p	84.5067	NM_001282405
NRBF2	hsa-miR-600	83.2463	NM_001282405
NRBF2	hsa-miR-3671	82.9049	NM_001282405
NRBF2	hsa-miR-3680-3p	81.8019	NM_001282405
NRBF2	hsa-miR-6875-3p	81.7481	NM_001282405
NRBF2	hsa-miR-301a-3p	81.4225	NM_001282405

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Motifs and transcription factors (TFs) regulating NRBF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRBF2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NRBF2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
NRBF2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
NRBF2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
NRBF2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
NRBF2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
NRBF2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
NRBF2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NRBF2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
NRBF2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
NRBF2	hdpi__FLI1	FLI1 (directAnnotation).
NRBF2	jaspar__MA1708.1	ETV7 (directAnnotation).
NRBF2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
NRBF2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
NRBF2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
NRBF2	transfac_pro__M00492	STAT1 (directAnnotation).
NRBF2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
NRBF2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NRBF2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
NRBF2	cisbp__M00341	PAX6 (directAnnotation).
NRBF2	metacluster_198.3	ZFP64 (directAnnotation).
NRBF2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NRBF2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
NRBF2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NRBF2	metacluster_175.1	ZNF283 (directAnnotation).
NRBF2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NRBF2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
NRBF2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NRBF2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
NRBF2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NRBF2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NRBF2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
NRBF2	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
NRBF2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NRBF2	metacluster_183.4	ETS1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."