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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NRARP

Summary for NRARP

Gene information	Gene symbol	NRARP
	Ensembl ID	ENSG00000198435
	Entrez ID	441478
	Gene name	NOTCH regulated ankyrin repeat protein
	Synonyms	MGC61598
	Gene type	protein_coding
	UniProtAcc	Q7Z6K4

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Dataset with differentially expressed gene: NRARP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.40421	1.49e-02
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	1.33794	0.00e+00

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Expression of NRARP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRARP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRARP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRARP	hsa-miR-3143	98.7601	NM_001004354
NRARP	hsa-miR-6508-5p	98.7447	NM_001004354
NRARP	hsa-miR-8067	98.1679	NM_001004354
NRARP	hsa-miR-302c-5p	97.797	NM_001004354
NRARP	hsa-miR-8485	97.2775	NM_001004354
NRARP	hsa-miR-6829-5p	96.1558	NM_001004354
NRARP	hsa-miR-12136	94.2881	NM_001004354
NRARP	hsa-miR-4803	93.9446	NM_001004354
NRARP	hsa-miR-3121-3p	93.2286	NM_001004354
NRARP	hsa-miR-340-5p	91.8767	NM_001004354
NRARP	hsa-miR-4282	90.0639	NM_001004354
NRARP	hsa-miR-4678	89.9489	NM_001004354
NRARP	hsa-miR-379-5p	89.4554	NM_001004354
NRARP	hsa-miR-185-3p	89.061	NM_001004354
NRARP	hsa-miR-27a-3p	88.7677	NM_001004354
NRARP	hsa-miR-27b-3p	88.7677	NM_001004354
NRARP	hsa-miR-9985	88.7677	NM_001004354
NRARP	hsa-miR-3163	88.2099	NM_001004354
NRARP	hsa-miR-215-3p	88.1771	NM_001004354
NRARP	hsa-miR-342-3p	87.6021	NM_001004354
NRARP	hsa-miR-499a-5p	87.0316	NM_001004354
NRARP	hsa-miR-3529-5p	86.8364	NM_001004354
NRARP	hsa-miR-152-3p	86.7599	NM_001004354
NRARP	hsa-miR-148b-3p	86.7599	NM_001004354
NRARP	hsa-miR-148a-3p	86.7599	NM_001004354
NRARP	hsa-miR-6832-3p	86.6038	NM_001004354
NRARP	hsa-miR-585-5p	84.5919	NM_001004354
NRARP	hsa-miR-4288	82.4185	NM_001004354
NRARP	hsa-miR-153-3p	82.371	NM_001004354
NRARP	hsa-miR-3664-3p	82.3481	NM_001004354
NRARP	hsa-miR-6787-5p	81.6959	NM_001004354
NRARP	hsa-miR-632	81.567	NM_001004354
NRARP	hsa-miR-4778-5p	81.3645	NM_001004354
NRARP	hsa-miR-487b-3p	80.955	NM_001004354
NRARP	hsa-miR-10396b-5p	80.7524	NM_001004354

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Motifs and transcription factors (TFs) regulating NRARP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRARP	transfac_pro__M02089	E2F3 (directAnnotation).
NRARP	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
NRARP	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NRARP	taipale_tf_pairs__TEAD4_ELK1_RMATWCCGGAWRN_CAP_repr	ELK1; TEAD4 (directAnnotation).
NRARP	transfac_pro__M06520	ZNF721 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."