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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NR4A3

Summary for NR4A3

Gene information	Gene symbol	NR4A3
	Ensembl ID	ENSG00000119508
	Entrez ID	8013
	Gene name	nuclear receptor subfamily 4 group A member 3
	Synonyms	CHN\|CSMF\|MINOR\|NOR1
	Gene type	protein_coding
	UniProtAcc	Q92570

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Dataset with differentially expressed gene: NR4A3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.288054	2.02e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.425849	1.14e-13
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.578639	5.30e-09
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.447624	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.399511	4.95e-35
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.394941	8.20e-13
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.334938	1.71e-29
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.761447	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.887248	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	1.59961	2.56e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.608806	1.37e-12

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Expression of NR4A3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NR4A3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NR4A3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NR4A3	hsa-miR-5011-5p	99.9994	NM_006981
NR4A3	hsa-miR-190a-3p	99.9957	NM_006981
NR4A3	hsa-miR-548p	99.1729	NM_006981
NR4A3	hsa-miR-576-5p	98.563	NM_006981
NR4A3	hsa-miR-10527-5p	97.2193	NM_006981
NR4A3	hsa-miR-9902	95.9926	NM_006981
NR4A3	hsa-let-7c-3p	95.9427	NM_006981
NR4A3	hsa-miR-5692b	95.6434	NM_006981
NR4A3	hsa-miR-5692c	95.6434	NM_006981
NR4A3	hsa-miR-29a-5p	95.4803	NM_006981
NR4A3	hsa-miR-651-3p	95.1678	NM_006981
NR4A3	hsa-miR-2355-5p	94.8152	NM_006981
NR4A3	hsa-miR-7-5p	94.6358	NM_006981
NR4A3	hsa-miR-4797-5p	94.0897	NM_006981
NR4A3	hsa-miR-6500-3p	93.9737	NM_006981
NR4A3	hsa-miR-302e	93.5827	NM_006981
NR4A3	hsa-miR-92a-3p	93.5812	NM_006981
NR4A3	hsa-miR-32-5p	93.5812	NM_006981
NR4A3	hsa-miR-367-3p	93.5812	NM_006981
NR4A3	hsa-miR-363-3p	93.5812	NM_006981
NR4A3	hsa-miR-92b-3p	93.5812	NM_006981
NR4A3	hsa-miR-25-3p	93.5812	NM_006981
NR4A3	hsa-miR-2053	93.2285	NM_006981
NR4A3	hsa-miR-1303	92.8535	NM_173199
NR4A3	hsa-miR-2116-5p	92.8286	NM_006981
NR4A3	hsa-miR-641	92.6585	NM_006981
NR4A3	hsa-miR-3617-5p	92.6585	NM_006981
NR4A3	hsa-miR-383-3p	91.7048	NM_006981
NR4A3	hsa-miR-6715b-3p	91.618	NM_006981
NR4A3	hsa-miR-6782-3p	91.6166	NM_006981
NR4A3	hsa-miR-3074-5p	91.2996	NM_006981
NR4A3	hsa-miR-3145-3p	90.9211	NM_006981
NR4A3	hsa-miR-3691-3p	90.9006	NM_006981
NR4A3	hsa-miR-3613-3p	90.844	NM_006981
NR4A3	hsa-miR-374a-5p	90.7512	NM_006981
NR4A3	hsa-miR-6772-5p	90.6209	NM_006981
NR4A3	hsa-miR-6504-5p	90.5969	NM_006981
NR4A3	hsa-miR-374b-5p	90.3947	NM_006981
NR4A3	hsa-miR-627-3p	89.7353	NM_006981
NR4A3	hsa-miR-1264	89.7012	NM_006981
NR4A3	hsa-miR-7161-5p	89.5796	NM_006981
NR4A3	hsa-miR-4325	88.9508	NM_006981
NR4A3	hsa-miR-6715a-3p	88.94	NM_006981
NR4A3	hsa-miR-6777-3p	88.8752	NM_006981
NR4A3	hsa-miR-3671	88.8623	NM_006981
NR4A3	hsa-miR-3910	88.7727	NM_173199
NR4A3	hsa-miR-4677-5p	88.7255	NM_006981
NR4A3	hsa-miR-587	88.6751	NM_006981
NR4A3	hsa-miR-5001-3p	88.2985	NM_006981
NR4A3	hsa-miR-548az-5p	88.1696	NM_006981

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Motifs and transcription factors (TFs) regulating NR4A3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NR4A3	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
NR4A3	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
NR4A3	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
NR4A3	transfac_pro__M08803	CREM (directAnnotation).
NR4A3	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
NR4A3	transfac_pro__M01861	ATF1 (directAnnotation).
NR4A3	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
NR4A3	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
NR4A3	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
NR4A3	tfdimers__MD00026	IRF1; MYB (directAnnotation).
NR4A3	metacluster_111.5	E4F1; E4F1 (directAnnotation).
NR4A3	metacluster_167.7	IRF8 (inferredBy_Orthology).
NR4A3	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
NR4A3	cisbp__M04023	CREB1 (directAnnotation).
NR4A3	hdpi__CREB1	CREB1 (directAnnotation).
NR4A3	transfac_pro__M01239	RELA (directAnnotation).
NR4A3	taipale_tf_pairs__ERF_MAX_RSCGGAANCACGTGN_CAP_repr	ERF; MAX (directAnnotation).
NR4A3	transfac_pro__M05397	ZNF444 (directAnnotation).
NR4A3	tfdimers__MD00031	MYB; ZEB1 (directAnnotation).
NR4A3	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
NR4A3	transfac_pro__M05464	SALL1 (directAnnotation).
NR4A3	hdpi__NFATC3	NFATC3 (directAnnotation).
NR4A3	transfac_pro__M07981	ATF3 (inferredBy_Orthology).
NR4A3	c2h2_zfs__M0385	MTF1 (inferredBy_Orthology).
NR4A3	metacluster_103.2	ZNF136; ZNF680 (directAnnotation).
NR4A3	transfac_pro__M06375	ZNF629 (inferredBy_Orthology).
NR4A3	metacluster_190.8	ILF2; NFAT5; NFAT5; NFAT5; NFAT5; NFATC1; NFATC2; NFATC3; NFATC4; NFATC4 (directAnnotation).
NR4A3	kznf__ZNF25_Imbeault2017_RP_ChIP-seq	ZNF25 (directAnnotation).
NR4A3	transfac_pro__M05419	ZBTB45 (directAnnotation).
NR4A3	transfac_pro__M01665	IRF8 (directAnnotation).
NR4A3	hdpi__RAB18	RAB18 (directAnnotation).
NR4A3	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
NR4A3	metacluster_70.1	POU5F1 (directAnnotation).
NR4A3	kznf__CTCF_Rhee2011.3_ChIP-exo	CTCF (directAnnotation).
NR4A3	transfac_pro__M05574	ZFP92 (directAnnotation).
NR4A3	transfac_pro__M05550	SNAPC4 (inferredBy_Orthology).
NR4A3	transfac_pro__M01251	E2F1 (directAnnotation).
NR4A3	tfdimers__MD00321	FLI1; ING4 (directAnnotation).
NR4A3	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
NR4A3	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
NR4A3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NR4A3	transfac_pro__M07436	WT1 (directAnnotation).
NR4A3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NR4A3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NR4A3	transfac_pro__M02089	E2F3 (directAnnotation).
NR4A3	metacluster_3.14	WT1; WT1 (directAnnotation).
NR4A3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NR4A3	transfac_pro__M04817	ZBTB33 (directAnnotation).
NR4A3	cisbp__M00968	MTF2 (directAnnotation).
NR4A3	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NR4A3	"Dasatinib"	DB01254	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."