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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NR2F2

Summary for NR2F2

Gene information	Gene symbol	NR2F2
	Ensembl ID	ENSG00000185551
	Entrez ID	7026
	Gene name	nuclear receptor subfamily 2 group F member 2
	Synonyms	ARP1\|COUP-TFII\|COUPTF2\|COUPTFB\|NF-E3\|SVP40\|TFCOUP2
	Gene type	protein_coding
	UniProtAcc	P24468

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Dataset with differentially expressed gene: NR2F2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.2513	9.10e-13
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.430047	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.420017	1.68e-31
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.26592	7.34e-34
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.503945	0.00e+00

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Expression of NR2F2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NR2F2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NR2F2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NR2F2	hsa-miR-4328	99.5096	NM_001145155
NR2F2	hsa-let-7a-3p	99.0784	NM_001145155
NR2F2	hsa-let-7b-3p	99.0784	NM_001145155
NR2F2	hsa-miR-98-3p	99.0784	NM_001145155
NR2F2	hsa-let-7f-1-3p	99.0784	NM_001145155
NR2F2	hsa-miR-5688	95.9927	NM_001145155
NR2F2	hsa-miR-495-3p	95.9927	NM_001145155
NR2F2	hsa-miR-3148	95.8538	NM_001145155
NR2F2	hsa-miR-4427	95.8046	NM_001145155
NR2F2	hsa-miR-4325	95.6709	NM_001145155
NR2F2	hsa-miR-3662	95.4325	NM_001145155
NR2F2	hsa-miR-4766-3p	93.4869	NM_001145155
NR2F2	hsa-miR-130b-5p	92.8557	NM_001145155
NR2F2	hsa-miR-3192-3p	92.4306	NM_001145155
NR2F2	hsa-miR-4527	91.8691	NM_001145155
NR2F2	hsa-miR-4725-3p	91.8382	NM_001145155
NR2F2	hsa-miR-5000-3p	91.8344	NM_001145155
NR2F2	hsa-miR-4436a	91.8344	NM_001145155
NR2F2	hsa-miR-561-3p	90.9124	NM_001145155
NR2F2	hsa-miR-4271	90.7313	NM_001145155
NR2F2	hsa-miR-6780b-5p	90.7313	NM_001145155
NR2F2	hsa-miR-144-3p	90.6978	NM_001145155
NR2F2	hsa-miR-497-3p	90.1525	NM_001145155
NR2F2	hsa-miR-3942-5p	89.9792	NM_001145155
NR2F2	hsa-miR-1323	89.9222	NM_001145155
NR2F2	hsa-miR-6503-5p	89.7339	NM_001145155
NR2F2	hsa-miR-4703-5p	89.4537	NM_001145155
NR2F2	hsa-miR-1236-3p	89.1083	NM_001145155
NR2F2	hsa-miR-5700	88.5196	NM_001145155
NR2F2	hsa-miR-513b-3p	88.5024	NM_001145155
NR2F2	hsa-miR-27a-3p	88.1267	NM_001145155
NR2F2	hsa-miR-27b-3p	88.1267	NM_001145155
NR2F2	hsa-miR-9985	88.1267	NM_001145155
NR2F2	hsa-miR-4748	87.9848	NM_001145155
NR2F2	hsa-miR-4464	87.9848	NM_001145155
NR2F2	hsa-miR-4494	87.9197	NM_001145155
NR2F2	hsa-miR-181b-3p	86.7685	NM_001145155
NR2F2	hsa-miR-181b-2-3p	86.7685	NM_001145155
NR2F2	hsa-miR-4420	86.7685	NM_001145155
NR2F2	hsa-miR-1252-5p	86.5239	NM_001145155
NR2F2	hsa-miR-6515-3p	86.3731	NM_001145155
NR2F2	hsa-miR-548o-3p	85.5513	NM_001145155
NR2F2	hsa-miR-4504	85.1944	NM_001145155
NR2F2	hsa-miR-202-5p	85.186	NM_001145155
NR2F2	hsa-miR-3686	84.6859	NM_001145155
NR2F2	hsa-miR-4512	84.6148	NM_001145155
NR2F2	hsa-miR-664b-3p	84.5584	NM_001145155
NR2F2	hsa-miR-579-3p	84.5584	NM_001145155
NR2F2	hsa-miR-595	84.4608	NM_001145155
NR2F2	hsa-miR-6892-3p	84.2339	NM_001145155

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Motifs and transcription factors (TFs) regulating NR2F2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NR2F2	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
NR2F2	taipale_tf_pairs__TFAP4_DLX3_NNCAGCTGNNNNNNNTAATTN_HT	DLX3; TFAP4 (directAnnotation).
NR2F2	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
NR2F2	transfac_pro__M08187	ABL1 (directAnnotation).
NR2F2	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
NR2F2	transfac_pro__M06512	ZNF461 (directAnnotation).
NR2F2	transfac_public__M00205	NR3C1 (directAnnotation).
NR2F2	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
NR2F2	hdpi__RFXANK	RFXANK (directAnnotation).
NR2F2	metacluster_161.4	LHX9 (directAnnotation).
NR2F2	metacluster_188.3	FOXJ3; FOXJ3; FOXP1; FOXP1 (directAnnotation). FOXO1; FOXO4; FOXP1 (inferredBy_Orthology).
NR2F2	metacluster_78.20	PAX7 (inferredBy_Orthology).
NR2F2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
NR2F2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NR2F2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
NR2F2	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
NR2F2	cisbp__M00808	MYPOP (inferredBy_Orthology).
NR2F2	hdpi__TP73	TP73 (directAnnotation).
NR2F2	transfac_pro__M07436	WT1 (directAnnotation).
NR2F2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NR2F2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NR2F2	transfac_pro__M02089	E2F3 (directAnnotation).
NR2F2	transfac_pro__M07329	SP7 (directAnnotation).
NR2F2	transfac_pro__M01122	ZNF219 (directAnnotation).
NR2F2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
NR2F2	metacluster_44.7	NKX3-2 (directAnnotation).
NR2F2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NR2F2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NR2F2	transfac_pro__M08819	KLF2 (directAnnotation).
NR2F2	transfac_pro__M01175	ZBTB7B (directAnnotation).
NR2F2	cisbp__M00249	WT1 (directAnnotation).
NR2F2	transfac_pro__M01118	WT1 (directAnnotation).
NR2F2	swissregulon__hs__KLF6	KLF6 (directAnnotation).
NR2F2	transfac_pro__M01303	SP1 (directAnnotation).
NR2F2	transfac_pro__M04595	SALL2 (directAnnotation).
NR2F2	transfac_pro__M01837	KLF11 (directAnnotation).
NR2F2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NR2F2	transfac_pro__M00716	ZBTB14 (directAnnotation).
NR2F2	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NR2F2	transfac_pro__M07397	ZNF148 (directAnnotation).
NR2F2	transfac_pro__M12686	ZBTB10 (directAnnotation).
NR2F2	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
NR2F2	transfac_pro__M01104	OVOL2 (directAnnotation).
NR2F2	transfac_pro__M06520	ZNF721 (directAnnotation).
NR2F2	transfac_pro__M00986	CHURC1 (directAnnotation).
NR2F2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NR2F2	transfac_pro__M03876	ZBTB33 (directAnnotation).
NR2F2	metacluster_7.13	ZFX (directAnnotation).
NR2F2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NR2F2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."