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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: NR2F1

Summary for NR2F1

Gene informationGene symbol

NR2F1

Ensembl ID

ENSG00000175745

Entrez ID

7025

Gene namenuclear receptor subfamily 2 group F member 1
SynonymsCOUP-TFI|COUPTF1|EAR-3|ERBAL3|SVP44|TCFCOUP1|TFCOUP1
Gene typeprotein_coding
UniProtAcc

P10589


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Dataset with differentially expressed gene: NR2F1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells0.5392060.00e+00

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells0.669010.00e+00

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells0.4936750.00e+00

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.8321460.00e+00

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Expression of NR2F1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to NR2F1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NR2F1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
NR2F1hsa-miR-366298.5265NM_005654
NR2F1hsa-miR-6867-5p97.675NM_005654
NR2F1hsa-miR-364697.0513NM_005654
NR2F1hsa-miR-5000-3p96.5843NM_005654
NR2F1hsa-miR-4436a96.5843NM_005654
NR2F1hsa-miR-3151-3p96.0772NM_005654
NR2F1hsa-miR-94494.0702NM_005654
NR2F1hsa-miR-520d-5p92.8634NM_005654
NR2F1hsa-miR-524-5p92.8634NM_005654
NR2F1hsa-miR-486-5p92.7348NM_005654
NR2F1hsa-miR-469891.7087NM_005654
NR2F1hsa-miR-7161-5p91.105NM_005654
NR2F1hsa-miR-3613-3p90.8232NM_005654
NR2F1hsa-miR-1236-3p90.6359NM_005654
NR2F1hsa-miR-990289.5962NM_005654
NR2F1hsa-miR-452889.3302NM_005654
NR2F1hsa-miR-1237-3p89.1973NM_005654
NR2F1hsa-miR-455-3p86.0238NM_005654
NR2F1hsa-miR-548u85.7129NM_005654
NR2F1hsa-miR-4446-5p84.8897NM_005654
NR2F1hsa-miR-5571-5p84.5248NM_005654
NR2F1hsa-miR-4700-3p84.0951NM_005654
NR2F1hsa-miR-806883.9139NM_005654
NR2F1hsa-miR-3074-3p83.5868NM_005654
NR2F1hsa-miR-7152-5p82.917NM_005654
NR2F1hsa-miR-376c-3p82.767NM_005654
NR2F1hsa-let-7a-2-3p82.4636NM_005654
NR2F1hsa-let-7g-3p82.4636NM_005654
NR2F1hsa-miR-106b-3p82.3604NM_005654
NR2F1hsa-miR-128982.2872NM_005654
NR2F1hsa-miR-513a-5p81.9221NM_005654
NR2F1hsa-miR-4723-3p81.7821NM_005654
NR2F1hsa-miR-6769b-3p81.7821NM_005654
NR2F1hsa-miR-318381.7821NM_005654
NR2F1hsa-miR-590-3p80.2426NM_005654
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Motifs and transcription factors (TFs) regulating NR2F1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
NR2F1metacluster_187.7FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
NR2F1metacluster_130.3ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
NR2F1swissregulon__mm__Atf2ATF2 (inferredBy_Orthology).
NR2F1transfac_pro__M05770ZNF77 (directAnnotation).
NR2F1transfac_pro__M06117ZNF23 (directAnnotation).
NR2F1swissregulon__hs__EZH2EZH2 (directAnnotation).
NR2F1metacluster_150.9VSX2; VSX2 (directAnnotation).
NR2F1jaspar__MA0079.5SP1 (directAnnotation).
NR2F1kznf__KLF1_Barrera2016.2_PBMKLF1 (directAnnotation).
NR2F1transfac_pro__M01253CNOT3 (directAnnotation).
NR2F1hdpi__NFIXNFIX (directAnnotation).
NR2F1metacluster_153.4SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
NR2F1transfac_pro__M04817ZBTB33 (directAnnotation).
NR2F1cisbp__M07938E2F1 (directAnnotation).
NR2F1transfac_pro__M05981ZNF233 (directAnnotation).
NR2F1transfac_pro__M04950EGR1 (directAnnotation).
NR2F1metacluster_172.6CHD2; E2F1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
NR2F1"beta-Naphthoflavone"

DB06732

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."