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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NR1H3

Summary for NR1H3

Gene information	Gene symbol	NR1H3
	Ensembl ID	ENSG00000025434
	Entrez ID	10062
	Gene name	nuclear receptor subfamily 1 group H member 3
	Synonyms	LXR-a\|LXRa\|RLD-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NR1H3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.410565	6.49e-39
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.808002	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.41259	2.88e-06

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Expression of NR1H3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NR1H3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NR1H3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NR1H3	hsa-miR-4668-5p	85.7566	NM_001130101
NR1H3	hsa-miR-6886-3p	85.2054	NM_001130101
NR1H3	hsa-miR-6840-3p	81.9559	NM_001130101

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Motifs and transcription factors (TFs) regulating NR1H3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NR1H3	metacluster_167.7	IRF8 (inferredBy_Orthology).
NR1H3	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
NR1H3	transfac_pro__M05612	ZNF189 (directAnnotation).
NR1H3	transfac_pro__M05418	ZNF521 (directAnnotation).
NR1H3	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
NR1H3	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).
NR1H3	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
NR1H3	metacluster_31.7	FOXO1; FOXO3; FOXO6 (directAnnotation).
NR1H3	taipale_tf_pairs__HOXB13_TBX21_ARGTGNNNNNNATAAA_CAP_repr	HOXB13; TBX21 (directAnnotation).
NR1H3	metacluster_12.1	ZNF3 (directAnnotation).
NR1H3	tfdimers__MD00395	NKX2-1; OTX1; OTX2 (directAnnotation).
NR1H3	transfac_pro__M06398	ZNF761 (directAnnotation).
NR1H3	transfac_pro__M06013	ZFP69B (directAnnotation).
NR1H3	transfac_pro__M06911	ZNF233 (inferredBy_Orthology).
NR1H3	transfac_pro__M06017	ZNF586 (directAnnotation).
NR1H3	transfac_pro__M06153	ZNF83 (directAnnotation).
NR1H3	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).
NR1H3	tfdimers__MD00433	NKX3-2; ZNF217 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NR1H3	"(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID"	DB08175	small molecule
NR1H3	"1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE"	DB08063	small molecule
NR1H3	"Diacerein"	DB11994	small molecule
NR1H3	"N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE"	DB07929	small molecule
NR1H3	"Rhein"	DB13174	small molecule
NR1H3	"TO-901317"	DB07080	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."