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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NQO1

Summary for NQO1

Gene information	Gene symbol	NQO1
	Ensembl ID	ENSG00000181019
	Entrez ID	1728
	Gene name	NAD(P)H quinone dehydrogenase 1
	Synonyms	DHQU\|DIA4\|DTD\|NMOR1\|QR1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NQO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.503813	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.44046	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.771012	2.50e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.414943	1.80e-12
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.757444	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.690614	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.616614	1.42e-23
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.653243	8.06e-35
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.524001	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.78302	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.712418	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.461307	0.00e+00

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Expression of NQO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NQO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NQO1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating NQO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NQO1	hsa-miR-6833-5p	97.6087	NM_001286137
NQO1	hsa-miR-3908	93.9179	NM_001286137
NQO1	hsa-miR-4452	93.7529	NM_000903
NQO1	hsa-miR-1912-3p	93.0168	NM_001286137
NQO1	hsa-miR-5100	92.421	NM_001286137
NQO1	hsa-miR-4752	89.9313	NM_001286137
NQO1	hsa-miR-1295b-5p	89.87	NM_001286137
NQO1	hsa-miR-217-3p	89.5396	NM_001286137
NQO1	hsa-miR-617	89.3357	NM_001286137
NQO1	hsa-miR-5197-3p	88.7411	NM_001286137
NQO1	hsa-miR-6892-3p	87.6038	NM_001286137
NQO1	hsa-miR-3133	87.0058	NM_001286137
NQO1	hsa-miR-605-3p	86.9611	NM_001286137
NQO1	hsa-miR-4659a-5p	86.7047	NM_001286137
NQO1	hsa-miR-4659b-5p	86.7047	NM_001286137
NQO1	hsa-miR-548l	85.5453	NM_001286137
NQO1	hsa-miR-6735-5p	85.501	NM_000903
NQO1	hsa-miR-4436b-3p	85.501	NM_000903
NQO1	hsa-miR-6879-5p	85.501	NM_000903
NQO1	hsa-miR-10397-3p	83.8278	NM_001286137
NQO1	hsa-miR-1184	83.3371	NM_001286137
NQO1	hsa-miR-7843-5p	83.2092	NM_000903
NQO1	hsa-miR-4632-5p	83.2092	NM_000903
NQO1	hsa-miR-5680	82.9889	NM_001286137
NQO1	hsa-miR-539-5p	82.5944	NM_000903
NQO1	hsa-miR-18b-3p	82.1013	NM_001286137
NQO1	hsa-miR-6499-3p	80.6077	NM_001286137
NQO1	hsa-miR-5088-3p	80.0505	NM_001286137

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Motifs and transcription factors (TFs) regulating NQO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NQO1	metacluster_70.16	POU5F1; POU5F1 (directAnnotation).
NQO1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
NQO1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
NQO1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
NQO1	metacluster_22.25	NFE2L2 (directAnnotation).
NQO1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
NQO1	metacluster_22.29	NFE2 (directAnnotation).
NQO1	metacluster_22.32	NFE2L2 (directAnnotation).
NQO1	metacluster_22.17	NFE2 (directAnnotation).
NQO1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
NQO1	metacluster_22.37	BACH1 (directAnnotation).
NQO1	metacluster_22.11	NFE2 (directAnnotation).
NQO1	metacluster_22.16	BACH2 (directAnnotation).
NQO1	metacluster_22.39	NFE2L2 (directAnnotation).
NQO1	metacluster_22.13	MAFK (inferredBy_Orthology).
NQO1	metacluster_22.20	MAFG (directAnnotation).
NQO1	metacluster_22.34	BACH2 (directAnnotation).
NQO1	metacluster_22.1	MAFF (inferredBy_Orthology).
NQO1	metacluster_22.18	BACH2 (inferredBy_Orthology).
NQO1	metacluster_155.30	ZNF254 (directAnnotation).
NQO1	transfac_pro__M05399	SCRT2 (inferredBy_Orthology).
NQO1	taipale_tf_pairs__E2F3_DRGX_SGCGCTAATTKN_CAP_repr	DRGX; E2F3 (directAnnotation).
NQO1	metacluster_26.2	ZNF264 (directAnnotation). NKX2-8 (inferredBy_Orthology).
NQO1	transfac_public__M00040	ATF2 (directAnnotation).
NQO1	metacluster_153.3	SOX10; SOX10; SOX18; SOX8; SOX8; SOX9; SOX9 (directAnnotation).
NQO1	metacluster_70.23	POU3F4 (directAnnotation).
NQO1	metacluster_156.4	NFIL3 (directAnnotation). NFIL3 (inferredBy_Orthology).
NQO1	metacluster_70.19	POU1F1 (directAnnotation).
NQO1	metacluster_70.22	POU3F2 (directAnnotation).
NQO1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
NQO1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
NQO1	cisbp__M02645	ETS1 (directAnnotation).
NQO1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NQO1	metacluster_22.15	BACH1 (directAnnotation).
NQO1	metacluster_22.14	BACH1 (inferredBy_Orthology).
NQO1	metacluster_22.28	BACH1 (directAnnotation).
NQO1	metacluster_22.19	NFE2 (directAnnotation).
NQO1	metacluster_22.36	BACH2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NQO1	"3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE"	DB07385	small molecule
NQO1	"3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol"	DB02395	small molecule
NQO1	"5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione"	DB03626	small molecule
NQO1	"Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]"	DB04392	small molecule
NQO1	"Cannabidiol"	DB09061	small molecule
NQO1	"Cibacron Blue"	DB02633	small molecule
NQO1	"Dicoumarol"	DB00266	small molecule
NQO1	"Duroquinone"	DB01927	small molecule
NQO1	"ES-936"	DB02400	small molecule
NQO1	"Flavin adenine dinucleotide"	DB03147	small molecule
NQO1	"Menadione"	DB00170	small molecule
NQO1	"RH-1"	DB04090	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."