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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NPL

Summary for NPL

Gene information	Gene symbol	NPL
	Ensembl ID	ENSG00000135838
	Entrez ID	80896
	Gene name	N-acetylneuraminate pyruvate lyase
	Synonyms	C1orf13\|DHDPS1\|NPL1
	Gene type	protein_coding
	UniProtAcc	Q9BXD5

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Dataset with differentially expressed gene: NPL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.283302	3.34e-28
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.633589	3.43e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.322146	2.23e-12
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.265198	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.367327	6.66e-24

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Expression of NPL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NPL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NPL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NPL	hsa-miR-4319	96.6334	NM_001200052
NPL	hsa-miR-125b-5p	96.257	NM_001200052
NPL	hsa-miR-125a-5p	96.257	NM_001200052
NPL	hsa-miR-3646	93.0677	NM_030769
NPL	hsa-miR-5094	92.6966	NM_001200052
NPL	hsa-miR-3154	91.8289	NM_001200051
NPL	hsa-miR-4672	91.7536	NM_001200051
NPL	hsa-miR-4284	87.602	NM_030769
NPL	hsa-miR-6844	87.1127	NM_030769
NPL	hsa-miR-6857-3p	86.9936	NM_030769
NPL	hsa-miR-4775	86.9648	NM_001200051
NPL	hsa-miR-383-3p	85.994	NM_001200052
NPL	hsa-miR-590-3p	85.6637	NM_001200051
NPL	hsa-miR-4306	84.9273	NM_030769
NPL	hsa-miR-3679-5p	84.9192	NM_001200051
NPL	hsa-miR-323a-3p	83.2692	NM_001200051
NPL	hsa-miR-539-5p	82.637	NM_001200052
NPL	hsa-miR-1185-5p	82.4166	NM_001200051
NPL	hsa-miR-140-5p	82.2247	NM_030769
NPL	hsa-miR-6732-3p	81.2901	NM_030769
NPL	hsa-miR-670-5p	80.6632	NM_001200052
NPL	hsa-miR-510-3p	80.2629	NM_030769

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Motifs and transcription factors (TFs) regulating NPL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NPL	transfac_pro__M06104	ZNF16 (directAnnotation).
NPL	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
NPL	metacluster_38.1	ETV7; ETV7; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT4; STAT5A; STAT5B (directAnnotation). STAT1; STAT3; STAT3; STAT4; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
NPL	transfac_pro__M06881	ZNF549 (directAnnotation).
NPL	transfac_pro__M01968	FOXO1 (directAnnotation).
NPL	metacluster_135.11	NR2C2 (directAnnotation).
NPL	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
NPL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NPL	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NPL	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
NPL	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
NPL	metacluster_22.13	MAFK (inferredBy_Orthology).
NPL	transfac_pro__M06402	ZNF493 (directAnnotation).
NPL	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
NPL	metacluster_155.35	FIZ1; ZNF322 (directAnnotation). ZNF322 (inferredBy_Orthology).
NPL	tfdimers__MD00208	IRF1; LTF (directAnnotation).
NPL	metacluster_29.2	BCL6; IRF3; IRF3; STAT1; STAT1; STAT1; STAT2; STAT3; STAT3; STAT3; STAT4; STAT4; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT5B; STAT6 (directAnnotation). STAT3; STAT5A; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
NPL	transfac_pro__M08190	AR (directAnnotation).
NPL	transfac_pro__M02012	HIF1A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."