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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NOVA1

Summary for NOVA1

Gene information	Gene symbol	NOVA1
	Ensembl ID	ENSG00000139910
	Entrez ID	4857
	Gene name	NOVA alternative splicing regulator 1
	Synonyms	NOVA-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NOVA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.389979	0.00e+00

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Expression of NOVA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NOVA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NOVA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NOVA1	hsa-miR-4789-5p	99.4337	NM_006489
NOVA1	hsa-miR-7153-5p	98.2783	NM_002515
NOVA1	hsa-miR-146b-5p	97.924	NM_002515
NOVA1	hsa-miR-146a-5p	97.924	NM_002515
NOVA1	hsa-miR-4753-3p	97.8139	NM_006489
NOVA1	hsa-miR-4481	97.4252	NM_002515
NOVA1	hsa-miR-199a-3p	97.3501	NM_002515
NOVA1	hsa-miR-3129-5p	97.3501	NM_002515
NOVA1	hsa-miR-199b-3p	97.3501	NM_002515
NOVA1	hsa-miR-3662	97.2806	NM_002515
NOVA1	hsa-miR-3925-5p	97.1767	NM_006489
NOVA1	hsa-miR-130b-5p	96.9198	NM_006489
NOVA1	hsa-miR-520f-5p	96.7709	NM_006489
NOVA1	hsa-miR-130a-5p	96.6741	NM_006489
NOVA1	hsa-miR-3646	96.5864	NM_006489
NOVA1	hsa-miR-494-3p	96.4603	NM_002515
NOVA1	hsa-miR-4745-5p	96.1147	NM_002515
NOVA1	hsa-miR-5582-3p	96.0027	NM_006489
NOVA1	hsa-miR-548j-3p	95.6733	NM_006489
NOVA1	hsa-miR-548am-3p	95.6733	NM_006489
NOVA1	hsa-miR-548ah-3p	95.6733	NM_006489
NOVA1	hsa-miR-548ae-3p	95.6733	NM_006489
NOVA1	hsa-miR-548aq-3p	95.6733	NM_006489
NOVA1	hsa-miR-548x-3p	95.4128	NM_006489
NOVA1	hsa-miR-548aj-3p	95.4128	NM_006489
NOVA1	hsa-miR-1252-3p	95.1389	NM_002515
NOVA1	hsa-miR-4729	95.0669	NM_006489
NOVA1	hsa-miR-126-5p	94.5231	NM_006489
NOVA1	hsa-miR-5000-5p	94.308	NM_006489
NOVA1	hsa-miR-4262	94.1301	NM_006489
NOVA1	hsa-miR-181d-5p	94.1301	NM_006489
NOVA1	hsa-miR-181b-5p	94.1301	NM_006489
NOVA1	hsa-miR-181c-5p	94.1301	NM_006489
NOVA1	hsa-miR-181a-5p	94.1301	NM_006489
NOVA1	hsa-miR-5579-3p	94.0927	NM_006491
NOVA1	hsa-miR-3976	93.4136	NM_006489
NOVA1	hsa-miR-4801	93.342	NM_006489
NOVA1	hsa-miR-1288-5p	93.2026	NM_006489
NOVA1	hsa-miR-3202	93.0508	NM_006489
NOVA1	hsa-miR-132-3p	92.9781	NM_006489
NOVA1	hsa-miR-212-3p	92.9781	NM_006489
NOVA1	hsa-miR-190b-3p	92.7702	NM_006489
NOVA1	hsa-miR-6809-3p	92.7421	NM_006489
NOVA1	hsa-miR-4799-5p	92.5948	NM_006489
NOVA1	hsa-miR-4490	92.3519	NM_006489
NOVA1	hsa-miR-600	91.8871	NM_006489
NOVA1	hsa-miR-551b-5p	91.7236	NM_006489
NOVA1	hsa-miR-4731-3p	91.5113	NM_006489
NOVA1	hsa-miR-133a-5p	91.1477	NM_006489
NOVA1	hsa-miR-6738-5p	91.0221	NM_002515

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Motifs and transcription factors (TFs) regulating NOVA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NOVA1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NOVA1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NOVA1	transfac_pro__M07397	ZNF148 (directAnnotation).
NOVA1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NOVA1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NOVA1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NOVA1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NOVA1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NOVA1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NOVA1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NOVA1	transfac_pro__M01175	ZBTB7B (directAnnotation).
NOVA1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NOVA1	tfdimers__MD00151	CHURC1 (directAnnotation).
NOVA1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NOVA1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NOVA1	transfac_pro__M01303	SP1 (directAnnotation).
NOVA1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NOVA1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NOVA1	transfac_pro__M02090	E2F4 (directAnnotation).
NOVA1	transfac_pro__M01714	KLF15 (directAnnotation).
NOVA1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NOVA1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NOVA1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NOVA1	transfac_pro__M02089	E2F3 (directAnnotation).
NOVA1	transfac_pro__M12604	ZNF444 (directAnnotation).
NOVA1	metacluster_3.14	WT1; WT1 (directAnnotation).
NOVA1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NOVA1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NOVA1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NOVA1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NOVA1	cisbp__M07938	E2F1 (directAnnotation).
NOVA1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
NOVA1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NOVA1	transfac_pro__M07436	WT1 (directAnnotation).
NOVA1	transfac_pro__M02281	SP1 (directAnnotation).
NOVA1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NOVA1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NOVA1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
NOVA1	transfac_pro__M02898	SMAD3 (directAnnotation).
NOVA1	transfac_public__M00491	PATZ1 (directAnnotation).
NOVA1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."