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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NNT

Summary for NNT

Gene information	Gene symbol	NNT
	Ensembl ID	ENSG00000112992
	Entrez ID	23530
	Gene name	nicotinamide nucleotide transhydrogenase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NNT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Mono/Macro	0.438884	1.10e-04

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Expression of NNT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NNT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NNT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NNT	hsa-miR-548ar-3p	94.9861	NM_182977
NNT	hsa-miR-548f-3p	94.6375	NM_182977
NNT	hsa-miR-548bc	94.6375	NM_182977
NNT	hsa-miR-548az-3p	94.6375	NM_182977
NNT	hsa-miR-548e-3p	94.6375	NM_182977
NNT	hsa-miR-548a-3p	94.576	NM_182977
NNT	hsa-miR-494-3p	93.4508	NM_182977
NNT	hsa-miR-138-2-3p	92.2167	NM_182977
NNT	hsa-miR-6833-3p	90.2323	NM_182977
NNT	hsa-miR-4540	89.8583	NM_182977
NNT	hsa-miR-4275	89.5557	NM_182977
NNT	hsa-miR-4766-5p	89.548	NM_182977
NNT	hsa-miR-653-5p	89.2425	NM_182977
NNT	hsa-miR-338-3p	87.6298	NM_182977
NNT	hsa-miR-4768-5p	87.3243	NM_182977
NNT	hsa-miR-3622a-5p	87.1615	NM_182977
NNT	hsa-miR-3140-3p	86.9476	NM_182977
NNT	hsa-miR-146a-3p	86.5124	NM_182977
NNT	hsa-miR-515-5p	83.5855	NM_182977
NNT	hsa-miR-607	83.0625	NM_182977
NNT	hsa-miR-519e-5p	80.2064	NM_182977

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Motifs and transcription factors (TFs) regulating NNT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NNT	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).
NNT	metacluster_44.5	NKX3-1 (inferredBy_Orthology).
NNT	metacluster_44.4	NKX3-1 (inferredBy_Orthology).
NNT	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
NNT	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
NNT	transfac_pro__M05941	ZNF471 (directAnnotation).
NNT	kznf__ZNF425_Imbeault2017_OM_MEME	ZNF425 (directAnnotation).
NNT	transfac_pro__M06465	ZNF595 (directAnnotation).
NNT	cisbp__M00808	MYPOP (inferredBy_Orthology).
NNT	transfac_pro__M05690	ZNF20 (directAnnotation).
NNT	transfac_pro__M05402	BCL6B (directAnnotation).
NNT	metacluster_52.16	FOXK1 (inferredBy_Orthology).
NNT	transfac_pro__M02191	SOX17 (inferredBy_Orthology).
NNT	homer__GTCACGCTCNCTGA_PAX5	PAX5 (directAnnotation).
NNT	taipale_tf_pairs__FLI1_HOXB13_NCCGGAANTNRTAAAN_HT	FLI1; HOXB13 (directAnnotation).
NNT	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NNT	transfac_pro__M04855	IRF4 (directAnnotation).
NNT	transfac_pro__M04918	EGR1 (directAnnotation).
NNT	transfac_pro__M05461	ZBTB4 (directAnnotation).
NNT	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNYAATTA_CAP	DLX3; ETV2 (directAnnotation).
NNT	transfac_pro__M05596	ZNF143 (directAnnotation).
NNT	metacluster_79.37	FOXJ3 (inferredBy_Orthology).
NNT	transfac_pro__M04879	JUN (directAnnotation).
NNT	transfac_pro__M05329	KLF16 (inferredBy_Orthology).
NNT	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NNT	"7-thionicotinamide-adenine-dinucleotide phosphate"	DB01763	small molecule
NNT	"NADH"	DB00157	small molecule
NNT	"Nicotinamide adenine dinucleotide phosphate"	DB03461	small molecule
NNT	"Xanthinol"	DB09092	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."