Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NME6

Summary for NME6

Gene information	Gene symbol	NME6
	Ensembl ID	ENSG00000172113
	Entrez ID	10201
	Gene name	NME/NM23 nucleoside diphosphate kinase 6
	Synonyms	IPIA-ALPHA\|NM23-H6
	Gene type	protein_coding
	UniProtAcc	O75414

Top

Dataset with differentially expressed gene: NME6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.415085	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.381803	4.75e-23
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.492471	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.341679	3.29e-17

Top

Expression of NME6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NME6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NME6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NME6	hsa-miR-4500	97.3718	NM_001308431
NME6	hsa-let-7g-5p	97.0548	NM_001308431
NME6	hsa-let-7d-5p	97.0548	NM_001308431
NME6	hsa-let-7i-5p	97.0548	NM_001308431
NME6	hsa-miR-4458	97.0548	NM_001308431
NME6	hsa-let-7c-5p	97.0548	NM_001308431
NME6	hsa-miR-98-5p	97.0548	NM_001308431
NME6	hsa-let-7a-5p	97.0548	NM_001308431
NME6	hsa-let-7e-5p	97.0548	NM_001308431
NME6	hsa-let-7f-5p	97.0548	NM_001308431
NME6	hsa-let-7b-5p	97.0548	NM_001308431
NME6	hsa-miR-525-5p	91.1997	NM_001308435
NME6	hsa-miR-520a-5p	91.1997	NM_001308435
NME6	hsa-miR-561-5p	91.0991	NM_001308435
NME6	hsa-miR-4296	88.5869	NM_001308435
NME6	hsa-miR-3927-3p	87.3242	NM_001308431
NME6	hsa-miR-6831-5p	87.3242	NM_001308431
NME6	hsa-miR-516b-5p	86.6925	NM_001308435
NME6	hsa-miR-378a-5p	86.0078	NM_001308435
NME6	hsa-miR-526b-5p	83.3293	NM_001308435
NME6	hsa-miR-3915	83.1856	NM_001308435
NME6	hsa-miR-5197-3p	82.6265	NM_001308431
NME6	hsa-miR-6778-3p	81.3334	NM_001308435
NME6	hsa-miR-4265	81.0856	NM_001308435
NME6	hsa-miR-4322	81.0856	NM_001308435
NME6	hsa-miR-4524a-3p	81.0665	NM_001308435

Page: 1

Top

Motifs and transcription factors (TFs) regulating NME6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NME6	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."