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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NMD3

Summary for NMD3

Gene information	Gene symbol	NMD3
	Ensembl ID	ENSG00000169251
	Entrez ID	51068
	Gene name	NMD3 ribosome export adaptor
	Synonyms	CGI-07
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NMD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.28631	1.45e-37
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.269975	2.66e-09

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Expression of NMD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NMD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NMD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NMD3	hsa-miR-3915	91.7237	NM_001320227
NMD3	hsa-miR-3680-3p	90.9351	NM_001320227
NMD3	hsa-miR-4775	90.9332	NM_015938
NMD3	hsa-miR-4279	90.5115	NM_015938
NMD3	hsa-miR-4495	90.3379	NM_015938
NMD3	hsa-miR-153-5p	90.1908	NM_015938
NMD3	hsa-miR-4753-3p	89.7854	NM_015938
NMD3	hsa-miR-3179	88.9569	NM_001320227
NMD3	hsa-miR-3920	88.8054	NM_015938
NMD3	hsa-miR-4460	87.818	NM_015938
NMD3	hsa-miR-4498	87.7957	NM_001320227
NMD3	hsa-miR-4492	86.9091	NM_001320227
NMD3	hsa-miR-762	86.9091	NM_001320227
NMD3	hsa-miR-5001-5p	86.9091	NM_001320227
NMD3	hsa-miR-3683	85.9608	NM_001320227
NMD3	hsa-miR-337-5p	85.147	NM_015938
NMD3	hsa-miR-4709-3p	84.5956	NM_015938
NMD3	hsa-miR-196a-1-3p	83.9718	NM_015938
NMD3	hsa-miR-651-3p	83.501	NM_015938
NMD3	hsa-miR-506-5p	83.4657	NM_015938
NMD3	hsa-miR-921	83.2514	NM_001320227
NMD3	hsa-miR-320a-5p	82.6006	NM_015938
NMD3	hsa-miR-6809-5p	81.669	NM_001320227
NMD3	hsa-miR-12124	80.7833	NM_015938
NMD3	hsa-miR-548c-3p	80.6889	NM_015938
NMD3	hsa-miR-3973	80.5294	NM_015938
NMD3	hsa-miR-3130-5p	80.3786	NM_001320227
NMD3	hsa-miR-4275	80.2191	NM_001320227
NMD3	hsa-miR-590-3p	80.2042	NM_015938

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Motifs and transcription factors (TFs) regulating NMD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NMD3	transfac_pro__M01861	ATF1 (directAnnotation).
NMD3	metacluster_98.1	ZNF524 (directAnnotation).
NMD3	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
NMD3	metacluster_135.11	NR2C2 (directAnnotation).
NMD3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NMD3	tfdimers__MD00038	TFAP2C (directAnnotation).
NMD3	metacluster_7.13	ZFX (directAnnotation).
NMD3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NMD3	cisbp__M00968	MTF2 (directAnnotation).
NMD3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
NMD3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
NMD3	cisbp__M00341	PAX6 (directAnnotation).
NMD3	metacluster_198.3	ZFP64 (directAnnotation).
NMD3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
NMD3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NMD3	cisbp__M00788	ZFY (inferredBy_Orthology).
NMD3	hdpi__ZNF304	ZNF304 (directAnnotation).
NMD3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NMD3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
NMD3	transfac_pro__M01199	TRIM28 (directAnnotation).
NMD3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
NMD3	metacluster_151.2	ZNF23 (directAnnotation).
NMD3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NMD3	transfac_pro__M03806	ZBTB7C (directAnnotation).
NMD3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."