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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NLN

Summary for NLN

Gene information	Gene symbol	NLN
	Ensembl ID	ENSG00000123213
	Entrez ID	57486
	Gene name	neurolysin
	Synonyms	AGTBP\|KIAA1226
	Gene type	protein_coding
	UniProtAcc	Q9BYT8

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Dataset with differentially expressed gene: NLN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.479145	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.353479	3.37e-19
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.250036	0.00e+00

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Expression of NLN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NLN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NLN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NLN	hsa-miR-4775	99.4537	NM_020726
NLN	hsa-miR-590-3p	99.1304	NM_020726
NLN	hsa-miR-6867-5p	96.7018	NM_020726
NLN	hsa-miR-520e-5p	96.4131	NM_020726
NLN	hsa-miR-570-3p	94.0128	NM_020726
NLN	hsa-miR-374a-5p	91.8854	NM_020726
NLN	hsa-miR-5688	91.7855	NM_020726
NLN	hsa-miR-4262	91.2883	NM_020726
NLN	hsa-miR-370-5p	90.8448	NM_020726
NLN	hsa-miR-455-3p	90.2355	NM_020726
NLN	hsa-miR-374b-5p	89.7034	NM_020726
NLN	hsa-miR-5696	89.5699	NM_020726
NLN	hsa-miR-495-3p	89.4728	NM_020726
NLN	hsa-miR-3146	88.9044	NM_020726
NLN	hsa-miR-181c-5p	88.7698	NM_020726
NLN	hsa-miR-181a-5p	88.7698	NM_020726
NLN	hsa-miR-181b-5p	88.7698	NM_020726
NLN	hsa-miR-181d-5p	88.7698	NM_020726
NLN	hsa-miR-504-3p	86.4574	NM_020726
NLN	hsa-miR-548s	86.3027	NM_020726
NLN	hsa-miR-450a-2-3p	86.184	NM_020726
NLN	hsa-miR-5193	86.1336	NM_020726
NLN	hsa-miR-3662	85.2273	NM_020726
NLN	hsa-miR-4687-5p	83.9293	NM_020726
NLN	hsa-miR-3148	83.6717	NM_020726
NLN	hsa-miR-551b-5p	83.5641	NM_020726
NLN	hsa-miR-664a-3p	83.3757	NM_020726
NLN	hsa-miR-627-3p	83.0996	NM_020726
NLN	hsa-miR-6809-3p	82.2718	NM_020726
NLN	hsa-miR-4738-3p	82.2596	NM_020726
NLN	hsa-miR-548m	82.0821	NM_020726
NLN	hsa-miR-6503-3p	81.914	NM_020726
NLN	hsa-miR-300	80.8457	NM_020726
NLN	hsa-miR-381-3p	80.8457	NM_020726
NLN	hsa-miR-4439	80.3914	NM_020726
NLN	hsa-miR-3136-5p	80.3914	NM_020726

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Motifs and transcription factors (TFs) regulating NLN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NLN	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
NLN	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NLN	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NLN	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NLN	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
NLN	jaspar__MA1122.1	TFDP1 (directAnnotation).
NLN	metacluster_160.20	JUND; PRDM15 (directAnnotation).
NLN	metacluster_198.3	ZFP64 (directAnnotation).
NLN	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."