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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NKTR

Summary for NKTR

Gene information	Gene symbol	NKTR
	Ensembl ID	ENSG00000114857
	Entrez ID	4820
	Gene name	natural killer cell triggering receptor
	Synonyms	p104
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NKTR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.314719	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.262005	3.61e-37
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.36478	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.310878	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.331657	4.59e-06
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.263366	1.38e-10
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.360737	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.39404	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.617454	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.320859	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.265284	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.327608	1.52e-22
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.473134	3.76e-17
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.323614	5.16e-03
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.373981	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.322171	0.00e+00

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Expression of NKTR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NKTR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NKTR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NKTR	hsa-miR-8485	99.3705	NM_005385
NKTR	hsa-miR-4742-3p	98.7318	NM_005385
NKTR	hsa-let-7a-3p	97.0102	NM_005385
NKTR	hsa-let-7f-1-3p	97.0102	NM_005385
NKTR	hsa-miR-98-3p	97.0102	NM_005385
NKTR	hsa-let-7b-3p	97.0102	NM_005385
NKTR	hsa-let-7c-3p	95.6758	NM_005385
NKTR	hsa-miR-107	91.7011	NM_005385
NKTR	hsa-miR-103a-3p	91.7011	NM_005385
NKTR	hsa-miR-12129	91.4582	NM_005385
NKTR	hsa-miR-153-5p	90.5264	NM_005385
NKTR	hsa-miR-1277-5p	89.695	NM_005385
NKTR	hsa-let-7f-2-3p	89.6919	NM_005385
NKTR	hsa-miR-1185-2-3p	89.6919	NM_005385
NKTR	hsa-miR-1185-1-3p	89.6919	NM_005385
NKTR	hsa-miR-630	89.3008	NM_005385
NKTR	hsa-miR-4699-3p	89.2714	NM_005385
NKTR	hsa-miR-4478	88.9187	NM_005385
NKTR	hsa-miR-4661-5p	88.4357	NM_005385
NKTR	hsa-miR-6511a-5p	87.9558	NM_005385
NKTR	hsa-miR-1910-3p	87.9558	NM_005385
NKTR	hsa-miR-3929	87.6581	NM_005385
NKTR	hsa-miR-524-5p	87.2999	NM_005385
NKTR	hsa-miR-520d-5p	87.2999	NM_005385
NKTR	hsa-miR-450b-5p	86.5494	NM_005385
NKTR	hsa-miR-3646	86.1785	NM_005385
NKTR	hsa-miR-4666a-3p	86.0745	NM_005385
NKTR	hsa-miR-29b-3p	86.03	NM_005385
NKTR	hsa-miR-29c-3p	86.03	NM_005385
NKTR	hsa-miR-29a-3p	86.03	NM_005385
NKTR	hsa-miR-300	85.3206	NM_005385
NKTR	hsa-miR-381-3p	85.3206	NM_005385
NKTR	hsa-miR-6776-5p	83.7325	NM_005385
NKTR	hsa-miR-664b-3p	82.3254	NM_005385
NKTR	hsa-miR-579-3p	82.3254	NM_005385
NKTR	hsa-miR-548au-3p	81.9594	NM_005385
NKTR	hsa-miR-875-3p	80.687	NM_005385
NKTR	hsa-miR-5696	80.1536	NM_005385

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Motifs and transcription factors (TFs) regulating NKTR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NKTR	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NKTR	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
NKTR	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NKTR	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NKTR	transfac_pro__M02090	E2F4 (directAnnotation).
NKTR	transfac_pro__M01714	KLF15 (directAnnotation).
NKTR	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NKTR	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NKTR	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
NKTR	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
NKTR	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NKTR	transfac_pro__M01973	PLAG1 (directAnnotation).
NKTR	cisbp__M01864	EGR1 (inferredBy_Orthology).
NKTR	tfdimers__MD00391	KLF4 (directAnnotation).
NKTR	cisbp__M00139	ZNF281 (inferredBy_Orthology).
NKTR	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
NKTR	tfdimers__MD00038	TFAP2C (directAnnotation).
NKTR	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
NKTR	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
NKTR	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
NKTR	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
NKTR	cisbp__M00249	WT1 (directAnnotation).
NKTR	tfdimers__MD00343	HIC1; TP53 (directAnnotation).
NKTR	transfac_public__M00373	PAX4 (directAnnotation).
NKTR	transfac_pro__M00938	E2F1 (directAnnotation).
NKTR	transfac_pro__M12667	GPBP1L1 (directAnnotation).
NKTR	cisbp__M00341	PAX6 (directAnnotation).
NKTR	transfac_pro__M08818	KLF8 (directAnnotation).
NKTR	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
NKTR	hdpi__TIMELESS	TIMELESS (directAnnotation).
NKTR	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NKTR	metacluster_191.5	SPDEF (inferredBy_Orthology).
NKTR	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
NKTR	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
NKTR	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
NKTR	metacluster_182.10	ZFX (directAnnotation).
NKTR	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
NKTR	metacluster_101.3	MYB (directAnnotation).
NKTR	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
NKTR	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
NKTR	transfac_pro__M06259	ZNF91 (directAnnotation).
NKTR	hdpi__FLI1	FLI1 (directAnnotation).
NKTR	taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTCGTAAAN_CAP	ETV4; HOXD12 (directAnnotation).
NKTR	transfac_pro__M06700	ZNF71 (directAnnotation).
NKTR	transfac_pro__M05472	ZBTB41 (directAnnotation).
NKTR	taipale_tf_pairs__PITX1_EOMES_GGATTANNARGTGTKN_CAP_repr	EOMES; PITX1 (directAnnotation).
NKTR	transfac_pro__M06241	ZNF345 (directAnnotation).
NKTR	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
NKTR	transfac_pro__M04944	GABPA (directAnnotation).
NKTR	hdpi__FEZF2	FEZF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."