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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: NKAPD1

Summary for NKAPD1

Gene informationGene symbol

NKAPD1

Ensembl ID

ENSG00000150776

Entrez ID

55216

Gene nameNKAP domain containing 1
SynonymsC11orf57|FLJ10726
Gene typeprotein_coding
UniProtAcc

Q6ZUT1


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Dataset with differentially expressed gene: NKAPD1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.3004875.04e-32

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Expression of NKAPD1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to NKAPD1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NKAPD1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
NKAPD1hsa-miR-942-3p98.5957NM_001082969
NKAPD1hsa-miR-4733-5p96.5357NM_001082969
NKAPD1hsa-miR-302f94.943NM_001082969
NKAPD1hsa-miR-1911-5p94.6914NM_001082969
NKAPD1hsa-miR-6834-3p91.9939NM_001082969
NKAPD1hsa-miR-548aw89.735NM_001082969
NKAPD1hsa-miR-29a-3p89.2362NM_001082969
NKAPD1hsa-miR-29b-3p89.2362NM_001082969
NKAPD1hsa-miR-29c-3p89.2362NM_001082969
NKAPD1hsa-miR-314889.0749NM_001082969
NKAPD1hsa-miR-196b-5p89.0648NM_001082969
NKAPD1hsa-miR-196a-5p89.0648NM_001082969
NKAPD1hsa-miR-5692a88.6012NM_001082969
NKAPD1hsa-miR-450088.3929NM_001082969
NKAPD1hsa-miR-137-3p88.067NM_001082969
NKAPD1hsa-miR-428287.4568NM_001082969
NKAPD1hsa-miR-98-5p87.1782NM_001082969
NKAPD1hsa-let-7c-5p87.1782NM_001082969
NKAPD1hsa-let-7d-5p87.1782NM_001082969
NKAPD1hsa-miR-445887.1782NM_001082969
NKAPD1hsa-let-7e-5p87.1782NM_001082969
NKAPD1hsa-let-7b-5p87.1782NM_001082969
NKAPD1hsa-let-7f-5p87.1782NM_001082969
NKAPD1hsa-let-7g-5p87.1782NM_001082969
NKAPD1hsa-let-7i-5p87.1782NM_001082969
NKAPD1hsa-let-7a-5p87.1782NM_001082969
NKAPD1hsa-miR-751586.5743NM_001082969
NKAPD1hsa-miR-6739-3p86.5385NM_001082969
NKAPD1hsa-miR-216b-5p85.8752NM_001082969
NKAPD1hsa-miR-391085.4912NM_001082969
NKAPD1hsa-miR-431985.3055NM_001082969
NKAPD1hsa-miR-211-5p82.872NM_001082969
NKAPD1hsa-miR-204-5p82.872NM_001082969
NKAPD1hsa-miR-557282.378NM_001082969
NKAPD1hsa-miR-138-5p82.3334NM_001082969
NKAPD1hsa-miR-5088-3p82.3022NM_001082969
NKAPD1hsa-miR-5584-5p82.2705NM_001082969
NKAPD1hsa-miR-125b-5p81.9698NM_001082969
NKAPD1hsa-miR-125a-5p81.9698NM_001082969
NKAPD1hsa-miR-4704-5p81.531NM_001082969
NKAPD1hsa-miR-454-3p81.2378NM_001082969
NKAPD1hsa-miR-3127-5p81.2114NM_001082969
NKAPD1hsa-miR-7157-3p80.9762NM_001082969
NKAPD1hsa-miR-6737-3p80.9762NM_001082969
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Motifs and transcription factors (TFs) regulating NKAPD1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."