Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NIPSNAP3A

Summary for NIPSNAP3A

Gene information	Gene symbol	NIPSNAP3A
	Ensembl ID	ENSG00000136783
	Entrez ID	25934
	Gene name	nipsnap homolog 3A
	Synonyms	DKFZp564D177\|FLJ13953\|HSPC299\|MGC14553\|NIPSNAP4\|TassC
	Gene type	protein_coding
	UniProtAcc	Q9UFN0

Top

Dataset with differentially expressed gene: NIPSNAP3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.573983	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.389857	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.327015	1.27e-32

Top

Expression of NIPSNAP3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NIPSNAP3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NIPSNAP3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NIPSNAP3A	hsa-miR-548ao-5p	93.7397	NM_015469
NIPSNAP3A	hsa-miR-548ax	93.7397	NM_015469
NIPSNAP3A	hsa-miR-1244	93.4493	NM_015469
NIPSNAP3A	hsa-miR-3614-3p	91.2829	NM_015469
NIPSNAP3A	hsa-miR-4777-5p	90.434	NM_015469
NIPSNAP3A	hsa-miR-587	85.9874	NM_015469
NIPSNAP3A	hsa-miR-6878-5p	85.8331	NM_015469
NIPSNAP3A	hsa-miR-3671	85.7389	NM_015469
NIPSNAP3A	hsa-miR-30c-1-3p	85.3616	NM_015469
NIPSNAP3A	hsa-miR-6788-5p	85.3616	NM_015469
NIPSNAP3A	hsa-miR-30c-2-3p	85.3616	NM_015469
NIPSNAP3A	hsa-miR-498-3p	84.5356	NM_015469
NIPSNAP3A	hsa-miR-5002-5p	83.9498	NM_015469
NIPSNAP3A	hsa-miR-205-5p	81.1956	NM_015469

Page: 1

Top

Motifs and transcription factors (TFs) regulating NIPSNAP3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NIPSNAP3A	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NIPSNAP3A	transfac_pro__M00652	NRF1 (directAnnotation).
NIPSNAP3A	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
NIPSNAP3A	metacluster_55.5	ZNF541 (directAnnotation).
NIPSNAP3A	transfac_pro__M04748	GABPA (directAnnotation).
NIPSNAP3A	transfac_pro__M04950	EGR1 (directAnnotation).
NIPSNAP3A	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."