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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NIPAL4

Summary for NIPAL4

Gene information	Gene symbol	NIPAL4
	Ensembl ID	ENSG00000172548
	Entrez ID	348938
	Gene name	NIPA like domain containing 4
	Synonyms	ICHYN\|SLC57A6
	Gene type	protein_coding
	UniProtAcc	Q0D2K0

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Dataset with differentially expressed gene: NIPAL4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.91507	1.92e-02

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Expression of NIPAL4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NIPAL4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NIPAL4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NIPAL4	hsa-miR-4319	97.6391	NM_001099287
NIPAL4	hsa-miR-125b-5p	97.2454	NM_001099287
NIPAL4	hsa-miR-125a-5p	97.2454	NM_001099287
NIPAL4	hsa-miR-202-3p	95.9405	NM_001099287
NIPAL4	hsa-miR-196a-1-3p	95.7007	NM_001172292
NIPAL4	hsa-miR-4500	95.476	NM_001099287
NIPAL4	hsa-miR-4262	95.0536	NM_001099287
NIPAL4	hsa-miR-3190-5p	94.8195	NM_001099287
NIPAL4	hsa-let-7c-5p	94.634	NM_001099287
NIPAL4	hsa-let-7b-5p	94.634	NM_001099287
NIPAL4	hsa-let-7i-5p	94.634	NM_001099287
NIPAL4	hsa-miR-98-5p	94.634	NM_001099287
NIPAL4	hsa-let-7a-5p	94.634	NM_001099287
NIPAL4	hsa-let-7e-5p	94.634	NM_001099287
NIPAL4	hsa-let-7g-5p	94.634	NM_001099287
NIPAL4	hsa-let-7f-5p	94.634	NM_001099287
NIPAL4	hsa-miR-9985	94.0487	NM_001099287
NIPAL4	hsa-miR-27a-3p	94.0487	NM_001099287
NIPAL4	hsa-miR-27b-3p	94.0487	NM_001099287
NIPAL4	hsa-let-7d-5p	93.2962	NM_001099287
NIPAL4	hsa-miR-4458	93.2962	NM_001099287
NIPAL4	hsa-miR-513c-5p	92.5387	NM_001172292
NIPAL4	hsa-miR-514b-5p	92.5387	NM_001172292
NIPAL4	hsa-miR-181c-5p	92.3452	NM_001099287
NIPAL4	hsa-miR-181a-5p	92.3452	NM_001099287
NIPAL4	hsa-miR-181d-5p	92.3452	NM_001099287
NIPAL4	hsa-miR-181b-5p	92.3452	NM_001099287
NIPAL4	hsa-miR-3180-5p	91.2195	NM_001099287
NIPAL4	hsa-miR-3663-3p	88.1326	NM_001172292
NIPAL4	hsa-miR-4747-5p	87.7921	NM_001172292
NIPAL4	hsa-miR-5196-5p	87.7921	NM_001172292
NIPAL4	hsa-miR-3176	87.2437	NM_001099287
NIPAL4	hsa-miR-4732-3p	86.8481	NM_001099287
NIPAL4	hsa-miR-345-3p	86.8481	NM_001099287
NIPAL4	hsa-miR-3922-3p	86.4169	NM_001099287
NIPAL4	hsa-miR-548s	85.7282	NM_001172292
NIPAL4	hsa-miR-670-5p	85.5624	NM_001099287
NIPAL4	hsa-miR-4487	85.0354	NM_001172292
NIPAL4	hsa-miR-4778-3p	84.2566	NM_001099287
NIPAL4	hsa-miR-221-3p	83.6261	NM_001099287
NIPAL4	hsa-miR-222-3p	83.6261	NM_001099287
NIPAL4	hsa-miR-4450	83.1782	NM_001172292
NIPAL4	hsa-miR-513a-5p	82.022	NM_001099287
NIPAL4	hsa-miR-33b-5p	81.9184	NM_001099287
NIPAL4	hsa-miR-33a-5p	81.9184	NM_001099287
NIPAL4	hsa-miR-4533	81.535	NM_001172292
NIPAL4	hsa-miR-5587-5p	80.714	NM_001099287

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Motifs and transcription factors (TFs) regulating NIPAL4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."