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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NIPA1

Summary for NIPA1

Gene information	Gene symbol	NIPA1
	Ensembl ID	ENSG00000288478
	Entrez ID	123606
	Gene name	NIPA magnesium transporter 1
	Synonyms	MGC35570\|SLC57A1\|SPG6
	Gene type	protein_coding
	UniProtAcc	Q7RTP0

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Dataset with differentially expressed gene: NIPA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.480459	0.00e+00

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Expression of NIPA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NIPA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NIPA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NIPA1	hsa-miR-6873-3p	99.6682	NM_001142275
NIPA1	hsa-miR-7110-3p	99.4445	NM_001142275
NIPA1	hsa-miR-5093	97.6977	NM_001142275
NIPA1	hsa-miR-607	96.2275	NM_001142275
NIPA1	hsa-miR-570-3p	95.8251	NM_001142275
NIPA1	hsa-miR-548an	93.7712	NM_001142275
NIPA1	hsa-miR-1250-3p	92.8822	NM_001142275
NIPA1	hsa-miR-1305	92.6099	NM_001142275
NIPA1	hsa-miR-6728-3p	92.4202	NM_001142275
NIPA1	hsa-miR-4307	92.3697	NM_001142275
NIPA1	hsa-miR-4699-3p	90.7147	NM_001142275
NIPA1	hsa-miR-3928-3p	90.4513	NM_001142275
NIPA1	hsa-miR-6817-3p	90.4272	NM_001142275
NIPA1	hsa-miR-1297	89.8489	NM_001142275
NIPA1	hsa-miR-526b-3p	89.3759	NM_001142275
NIPA1	hsa-miR-106b-5p	88.5842	NM_001142275
NIPA1	hsa-miR-20a-5p	88.5842	NM_001142275
NIPA1	hsa-miR-20b-5p	88.5513	NM_001142275
NIPA1	hsa-miR-17-5p	88.5513	NM_001142275
NIPA1	hsa-miR-93-5p	88.5513	NM_001142275
NIPA1	hsa-miR-519d-3p	88.5513	NM_001142275
NIPA1	hsa-miR-106a-5p	88.5513	NM_001142275
NIPA1	hsa-miR-12113	88.4519	NM_001142275
NIPA1	hsa-miR-587	87.9305	NM_001142275
NIPA1	hsa-miR-6781-3p	87.2679	NM_001142275
NIPA1	hsa-miR-33a-3p	86.6977	NM_001142275
NIPA1	hsa-miR-3976	85.4514	NM_001142275
NIPA1	hsa-miR-4539	85.3973	NM_001142275
NIPA1	hsa-miR-454-5p	84.9141	NM_001142275
NIPA1	hsa-miR-6744-5p	84.5873	NM_001142275
NIPA1	hsa-miR-4319	84.3115	NM_001142275
NIPA1	hsa-miR-125b-5p	84.3115	NM_001142275
NIPA1	hsa-miR-125a-5p	84.3115	NM_001142275
NIPA1	hsa-miR-4666a-5p	84.136	NM_001142275
NIPA1	hsa-miR-2682-3p	83.6727	NM_001142275
NIPA1	hsa-miR-6828-5p	83.3761	NM_001142275
NIPA1	hsa-miR-335-3p	83.1535	NM_001142275
NIPA1	hsa-miR-328-5p	83.093	NM_001142275
NIPA1	hsa-miR-6885-5p	83.093	NM_001142275
NIPA1	hsa-miR-3646	83.0023	NM_001142275
NIPA1	hsa-miR-202-3p	82.3089	NM_001142275
NIPA1	hsa-miR-3123	82.201	NM_001142275
NIPA1	hsa-miR-26a-5p	81.8703	NM_001142275
NIPA1	hsa-miR-26b-5p	81.8703	NM_001142275
NIPA1	hsa-miR-4652-3p	81.8496	NM_001142275
NIPA1	hsa-miR-558	80.5936	NM_001142275
NIPA1	hsa-miR-4659a-3p	80.5662	NM_001142275
NIPA1	hsa-miR-4659b-3p	80.5662	NM_001142275
NIPA1	hsa-miR-642a-3p	80.3728	NM_001142275
NIPA1	hsa-miR-642b-3p	80.3728	NM_001142275

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Motifs and transcription factors (TFs) regulating NIPA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NIPA1	metacluster_135.11	NR2C2 (directAnnotation).
NIPA1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NIPA1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NIPA1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
NIPA1	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."