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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NHSL1

Summary for NHSL1

Gene information	Gene symbol	NHSL1
	Ensembl ID	ENSG00000135540
	Entrez ID	57224
	Gene name	NHS like 1
	Synonyms	bA43P8.1\|C6orf63\|KIAA1357
	Gene type	protein_coding
	UniProtAcc	Q5SYE7

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Dataset with differentially expressed gene: NHSL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.432296	2.59e-40
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.263489	7.82e-21

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Expression of NHSL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NHSL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NHSL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NHSL1	hsa-miR-7-1-3p	98.324	NM_001144060
NHSL1	hsa-miR-7-2-3p	98.324	NM_001144060
NHSL1	hsa-miR-223-5p	96.1106	NM_001144060
NHSL1	hsa-miR-7849-3p	94.3884	NM_001144060
NHSL1	hsa-miR-4516	93.3899	NM_001144060
NHSL1	hsa-miR-4434	93.3899	NM_001144060
NHSL1	hsa-miR-5703	92.675	NM_001144060
NHSL1	hsa-miR-940	90.9822	NM_001144060
NHSL1	hsa-miR-6808-5p	90.9822	NM_001144060
NHSL1	hsa-miR-6893-5p	90.9822	NM_001144060
NHSL1	hsa-miR-34b-5p	90.6375	NM_001144060
NHSL1	hsa-miR-449c-5p	90.6375	NM_001144060
NHSL1	hsa-miR-3184-3p	89.9692	NM_001144060
NHSL1	hsa-miR-2682-5p	89.5331	NM_001144060
NHSL1	hsa-miR-335-3p	89.4809	NM_001144060
NHSL1	hsa-miR-4450	88.7569	NM_001144060
NHSL1	hsa-miR-6764-5p	86.2696	NM_001144060
NHSL1	hsa-miR-548p	86.1335	NM_001144060
NHSL1	hsa-miR-1915-3p	85.2932	NM_001144060
NHSL1	hsa-miR-3973	84.8487	NM_001144060
NHSL1	hsa-miR-4762-3p	84.3533	NM_001144060
NHSL1	hsa-miR-122b-5p	83.9563	NM_001144060
NHSL1	hsa-miR-6835-5p	83.3318	NM_001144060
NHSL1	hsa-miR-1253	82.6689	NM_001144060
NHSL1	hsa-miR-5684	82.3349	NM_001144060
NHSL1	hsa-miR-7161-5p	81.8749	NM_001144060

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Motifs and transcription factors (TFs) regulating NHSL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NHSL1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NHSL1	cisbp__M02645	ETS1 (directAnnotation).
NHSL1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
NHSL1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
NHSL1	hdpi__TP73	TP73 (directAnnotation).
NHSL1	hdpi__FLI1	FLI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."