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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NHLH1

Summary for NHLH1

Gene information	Gene symbol	NHLH1
	Ensembl ID	ENSG00000171786
	Entrez ID	4807
	Gene name	nescient helix-loop-helix 1
	Synonyms	bHLHa35\|HEN1\|NSCL\|NSCL1
	Gene type	protein_coding
	UniProtAcc	Q02575

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Dataset with differentially expressed gene: NHLH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.957016	0.00e+00

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Expression of NHLH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NHLH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NHLH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NHLH1	hsa-miR-5692a	99.9827	NM_005598
NHLH1	hsa-miR-7162-3p	92.603	NM_005598
NHLH1	hsa-miR-4773	88.2878	NM_005598
NHLH1	hsa-miR-4700-5p	85.9067	NM_005598
NHLH1	hsa-miR-7154-3p	84.8423	NM_005598
NHLH1	hsa-miR-1827	84.7789	NM_005598
NHLH1	hsa-miR-4703-5p	84.7547	NM_005598
NHLH1	hsa-miR-6127	84.2311	NM_005598
NHLH1	hsa-miR-3942-5p	83.1121	NM_005598
NHLH1	hsa-miR-4999-3p	82.3956	NM_005598
NHLH1	hsa-miR-4732-5p	82.3365	NM_005598
NHLH1	hsa-miR-6830-5p	81.9603	NM_005598
NHLH1	hsa-miR-6133	81.5593	NM_005598
NHLH1	hsa-miR-3149	80.9982	NM_005598
NHLH1	hsa-miR-8089	80.7924	NM_005598
NHLH1	hsa-miR-4667-5p	80.7924	NM_005598
NHLH1	hsa-miR-637	80.3983	NM_005598

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Motifs and transcription factors (TFs) regulating NHLH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NHLH1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NHLH1	transfac_pro__M01714	KLF15 (directAnnotation).
NHLH1	transfac_pro__M02281	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."