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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NFX1

Summary for NFX1

Gene information	Gene symbol	NFX1
	Ensembl ID	ENSG00000086102
	Entrez ID	4799
	Gene name	nuclear transcription factor, X-box binding 1
	Synonyms	MGC20369\|NFX2\|TEG-42\|Tex42
	Gene type	protein_coding
	UniProtAcc	Q12986

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Dataset with differentially expressed gene: NFX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.381807	0.00e+00

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Expression of NFX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NFX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NFX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NFX1	hsa-miR-128-3p	94.3554	NM_001318758
NFX1	hsa-miR-216a-3p	94.3554	NM_001318758
NFX1	hsa-miR-3681-3p	93.467	NM_001318758
NFX1	hsa-miR-6778-3p	86.4199	NM_147134
NFX1	hsa-miR-3692-5p	85.9981	NM_001318758
NFX1	hsa-miR-4436b-3p	84.6242	NM_001318758
NFX1	hsa-miR-890	84.5185	NM_001318758
NFX1	hsa-miR-7112-3p	84.4259	NM_147134
NFX1	hsa-miR-548at-5p	84.3623	NM_001318758
NFX1	hsa-miR-629-5p	84.173	NM_001318758
NFX1	hsa-miR-4505	83.6368	NM_001318758
NFX1	hsa-miR-5787	83.6368	NM_001318758
NFX1	hsa-miR-8062	83.2881	NM_147134
NFX1	hsa-miR-4283	83.226	NM_001318758
NFX1	hsa-miR-9851-5p	82.8774	NM_001318758
NFX1	hsa-miR-3144-3p	82.3208	NM_001318758
NFX1	hsa-miR-142-5p	80.5823	NM_001318758
NFX1	hsa-miR-5590-3p	80.5714	NM_001318758

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Motifs and transcription factors (TFs) regulating NFX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."