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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NFIA

Summary for NFIA

Gene information	Gene symbol	NFIA
	Ensembl ID	ENSG00000162599
	Entrez ID	4774
	Gene name	nuclear factor I A
	Synonyms	KIAA1439\|NFI-L
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NFIA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.936482	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.433283	2.21e-25
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.831553	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.624914	3.33e-42
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.295319	2.09e-10

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Expression of NFIA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NFIA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NFIA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NFIA	hsa-miR-3148	99.7961	NM_005595
NFIA	hsa-miR-3613-3p	99.7521	NM_005595
NFIA	hsa-miR-767-5p	99.6728	NM_001134673
NFIA	hsa-miR-653-5p	99.4625	NM_001134673
NFIA	hsa-miR-4716-5p	98.8244	NM_001134673
NFIA	hsa-miR-651-3p	98.761	NM_005595
NFIA	hsa-miR-4795-3p	98.5492	NM_005595
NFIA	hsa-miR-548c-3p	98.053	NM_001134673
NFIA	hsa-miR-29c-3p	97.9342	NM_001134673
NFIA	hsa-miR-29a-3p	97.9342	NM_001134673
NFIA	hsa-miR-29b-3p	97.9342	NM_001134673
NFIA	hsa-miR-126-5p	97.4816	NM_005595
NFIA	hsa-miR-448	97.3628	NM_001134673
NFIA	hsa-miR-5688	97.1426	NM_005595
NFIA	hsa-miR-495-3p	97.1426	NM_005595
NFIA	hsa-miR-599	97.0912	NM_005595
NFIA	hsa-miR-429	97.0502	NM_001134673
NFIA	hsa-miR-200b-3p	97.0502	NM_001134673
NFIA	hsa-miR-200c-3p	97.0502	NM_001134673
NFIA	hsa-miR-302e	96.8175	NM_001134673
NFIA	hsa-miR-4638-3p	96.5982	NM_001134673
NFIA	hsa-miR-592	96.5865	NM_001134673
NFIA	hsa-miR-548l	96.5643	NM_001134673
NFIA	hsa-miR-1228-3p	96.3817	NM_001134673
NFIA	hsa-miR-335-3p	96.1335	NM_005595
NFIA	hsa-miR-5010-3p	96.0662	NM_005595
NFIA	hsa-miR-6770-5p	95.8985	NM_001134673
NFIA	hsa-miR-4668-5p	95.8122	NM_005595
NFIA	hsa-miR-4671-3p	95.7056	NM_001134673
NFIA	hsa-miR-12120	95.5588	NM_001134673
NFIA	hsa-miR-3120-5p	95.1841	NM_001134673
NFIA	hsa-miR-4456	95.0982	NM_001134673
NFIA	hsa-miR-302a-3p	95.0017	NM_001134673
NFIA	hsa-miR-302b-3p	95.0017	NM_001134673
NFIA	hsa-miR-302d-3p	95.0017	NM_001134673
NFIA	hsa-miR-302c-3p	95.0017	NM_001134673
NFIA	hsa-miR-548e-5p	94.9295	NM_001134673
NFIA	hsa-miR-153-3p	94.7603	NM_001134673
NFIA	hsa-miR-520a-3p	94.2362	NM_001134673
NFIA	hsa-miR-373-3p	94.2362	NM_001134673
NFIA	hsa-miR-520d-3p	94.2362	NM_001134673
NFIA	hsa-miR-520b-3p	94.2362	NM_001134673
NFIA	hsa-miR-520c-3p	94.2362	NM_001134673
NFIA	hsa-miR-372-3p	94.2362	NM_001134673
NFIA	hsa-miR-520e-3p	94.2362	NM_001134673
NFIA	hsa-miR-4797-5p	93.9381	NM_001134673
NFIA	hsa-miR-524-5p	93.6632	NM_005595
NFIA	hsa-miR-520d-5p	93.6632	NM_005595
NFIA	hsa-miR-12136	93.3075	NM_005595
NFIA	hsa-miR-517b-3p	92.8186	NM_001134673

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Motifs and transcription factors (TFs) regulating NFIA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NFIA	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NFIA	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NFIA	transfac_pro__M07397	ZNF148 (directAnnotation).
NFIA	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NFIA	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NFIA	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NFIA	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NFIA	metacluster_7.13	ZFX (directAnnotation).
NFIA	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NFIA	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NFIA	transfac_pro__M01175	ZBTB7B (directAnnotation).
NFIA	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NFIA	tfdimers__MD00151	CHURC1 (directAnnotation).
NFIA	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NFIA	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NFIA	transfac_pro__M01303	SP1 (directAnnotation).
NFIA	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NFIA	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NFIA	transfac_pro__M02090	E2F4 (directAnnotation).
NFIA	transfac_pro__M01714	KLF15 (directAnnotation).
NFIA	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NFIA	jaspar__MA1122.1	TFDP1 (directAnnotation).
NFIA	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NFIA	transfac_pro__M02089	E2F3 (directAnnotation).
NFIA	metacluster_3.14	WT1; WT1 (directAnnotation).
NFIA	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NFIA	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NFIA	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NFIA	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NFIA	cisbp__M07938	E2F1 (directAnnotation).
NFIA	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NFIA	transfac_pro__M07436	WT1 (directAnnotation).
NFIA	transfac_pro__M02281	SP1 (directAnnotation).
NFIA	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NFIA	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NFIA	transfac_pro__M02898	SMAD3 (directAnnotation).
NFIA	transfac_public__M00491	PATZ1 (directAnnotation).
NFIA	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NFIA	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
NFIA	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NFIA	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
NFIA	transfac_pro__M00652	NRF1 (directAnnotation).
NFIA	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
NFIA	transfac_pro__M01298	MECP2 (directAnnotation).
NFIA	transfac_pro__M04918	EGR1 (directAnnotation).
NFIA	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
NFIA	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
NFIA	hdpi__TP73	TP73 (directAnnotation).
NFIA	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
NFIA	jaspar__MA1460.1	YY1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."