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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NF2

Summary for NF2

Gene information	Gene symbol	NF2
	Ensembl ID	ENSG00000186575
	Entrez ID	4771
	Gene name	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
	Synonyms	ACN\|BANF\|merlin\|merlin-1\|SCH
	Gene type	protein_coding
	UniProtAcc	P35240

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Dataset with differentially expressed gene: NF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.2634	2.06e-06
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.275972	1.70e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.589553	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.488746	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.320956	0.00e+00

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Expression of NF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NF2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating NF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NF2	hsa-miR-616-5p	98.2814	NM_181833
NF2	hsa-miR-373-5p	98.2814	NM_181833
NF2	hsa-miR-371b-5p	98.2814	NM_181833
NF2	hsa-miR-1827	97.7117	NM_181833
NF2	hsa-miR-4486	96.9611	NM_181832
NF2	hsa-miR-1291	96.2751	NM_181833
NF2	hsa-miR-378g	96.2718	NM_181832
NF2	hsa-miR-6775-3p	95.7551	NM_181833
NF2	hsa-miR-7-5p	91.7403	NM_181833
NF2	hsa-miR-2355-5p	91.6981	NM_181833
NF2	hsa-miR-3613-3p	90.5621	NM_181833
NF2	hsa-miR-5001-3p	90.5244	NM_181833
NF2	hsa-miR-7106-3p	90.0117	NM_181832
NF2	hsa-miR-4722-5p	89.7391	NM_181831
NF2	hsa-miR-25-3p	88.7614	NM_181830
NF2	hsa-miR-4768-3p	88.7052	NM_181833
NF2	hsa-miR-1285-3p	88.5473	NM_181832
NF2	hsa-miR-5189-5p	88.5473	NM_181832
NF2	hsa-miR-32-5p	88.4401	NM_181830
NF2	hsa-miR-363-3p	88.4401	NM_181830
NF2	hsa-miR-92b-3p	88.4401	NM_181830
NF2	hsa-miR-92a-3p	88.4401	NM_181830
NF2	hsa-miR-367-3p	88.4401	NM_181830
NF2	hsa-miR-4505	88.1066	NM_181830
NF2	hsa-miR-5787	88.0421	NM_181830
NF2	hsa-miR-3187-5p	87.1497	NM_181832
NF2	hsa-miR-6860	87.1497	NM_181832
NF2	hsa-miR-612	87.09	NM_181832
NF2	hsa-miR-6808-5p	86.4241	NM_181833
NF2	hsa-miR-6893-5p	86.4241	NM_181833
NF2	hsa-miR-940	86.4241	NM_181833
NF2	hsa-miR-489-3p	85.9267	NM_181833
NF2	hsa-miR-3614-3p	84.0471	NM_181833
NF2	hsa-miR-4728-5p	83.6737	NM_181833
NF2	hsa-miR-4691-3p	83.0976	NM_181833
NF2	hsa-miR-4492	82.4107	NM_181833
NF2	hsa-miR-4509	81.9308	NM_181825
NF2	hsa-miR-6796-3p	81.1759	NM_181825
NF2	hsa-miR-6785-5p	80.6736	NM_181833
NF2	hsa-miR-6858-3p	80.3916	NM_181833
NF2	hsa-miR-193a-3p	80.1662	NM_181833
NF2	hsa-miR-193b-3p	80.1662	NM_181833

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Motifs and transcription factors (TFs) regulating NF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NF2	metacluster_7.13	ZFX (directAnnotation).
NF2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
NF2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
NF2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
NF2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NF2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
NF2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
NF2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NF2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
NF2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
NF2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NF2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
NF2	transfac_pro__M00652	NRF1 (directAnnotation).
NF2	transfac_pro__M04866	HDAC2 (directAnnotation).
NF2	jaspar__MA1122.1	TFDP1 (directAnnotation).
NF2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
NF2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NF2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NF2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
NF2	cisbp__M08198	ELF1 (directAnnotation).
NF2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
NF2	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."