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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NEURL1B

Summary for NEURL1B

Gene information	Gene symbol	NEURL1B
	Ensembl ID	ENSG00000214357
	Entrez ID	54492
	Gene name	neuralized E3 ubiquitin protein ligase 1B
	Synonyms	DKFZP761M1511\|Neur2\|RNF67B
	Gene type	protein_coding
	UniProtAcc	A8MQ27

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Dataset with differentially expressed gene: NEURL1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.36788	0.00e+00

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Expression of NEURL1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NEURL1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NEURL1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NEURL1B	hsa-miR-7110-3p	99.0866	NM_001142651
NEURL1B	hsa-miR-6873-3p	98.6163	NM_001142651
NEURL1B	hsa-miR-4755-3p	97.2916	NM_001142651
NEURL1B	hsa-miR-29b-1-5p	97.0671	NM_001142651
NEURL1B	hsa-miR-12136	95.242	NM_001142651
NEURL1B	hsa-miR-30c-5p	95.0582	NM_001142651
NEURL1B	hsa-miR-30b-5p	95.0582	NM_001142651
NEURL1B	hsa-miR-30e-5p	95.0582	NM_001142651
NEURL1B	hsa-miR-30d-5p	95.0582	NM_001142651
NEURL1B	hsa-miR-30a-5p	95.0582	NM_001142651
NEURL1B	hsa-miR-1468-3p	92.2954	NM_001142651
NEURL1B	hsa-miR-1200	92.1644	NM_001142651
NEURL1B	hsa-miR-2115-3p	92.0666	NM_001142651
NEURL1B	hsa-miR-6764-5p	91.7016	NM_001142651
NEURL1B	hsa-miR-2355-5p	91.0599	NM_001142651
NEURL1B	hsa-miR-506-3p	90.3999	NM_001142651
NEURL1B	hsa-miR-124-3p	90.3999	NM_001142651
NEURL1B	hsa-miR-12122	90.133	NM_001142651
NEURL1B	hsa-miR-4446-5p	89.9801	NM_001142651
NEURL1B	hsa-miR-6842-5p	89.3696	NM_001142651
NEURL1B	hsa-miR-7110-5p	89.3696	NM_001142651
NEURL1B	hsa-miR-9985	89.1307	NM_001142651
NEURL1B	hsa-miR-27b-3p	89.1307	NM_001142651
NEURL1B	hsa-miR-27a-3p	89.1307	NM_001142651
NEURL1B	hsa-miR-8485	88.8031	NM_001142651
NEURL1B	hsa-miR-1915-3p	88.7275	NM_001142651
NEURL1B	hsa-miR-6752-5p	88.4253	NM_001142651
NEURL1B	hsa-miR-4667-3p	88.2863	NM_001142651
NEURL1B	hsa-miR-12125	88.1369	NM_001142651
NEURL1B	hsa-miR-6768-5p	87.7964	NM_001142651
NEURL1B	hsa-miR-4726-3p	87.5426	NM_001142651
NEURL1B	hsa-miR-342-3p	86.8136	NM_001142651
NEURL1B	hsa-miR-500b-3p	86.7856	NM_001142651
NEURL1B	hsa-miR-3619-5p	86.4481	NM_001142651
NEURL1B	hsa-miR-5584-5p	86.3583	NM_001142651
NEURL1B	hsa-miR-15b-3p	85.8274	NM_001142651
NEURL1B	hsa-miR-6817-3p	85.5696	NM_001142651
NEURL1B	hsa-miR-8068	84.5219	NM_001142651
NEURL1B	hsa-miR-223-5p	82.4254	NM_001142651
NEURL1B	hsa-miR-885-3p	82.3164	NM_001142651
NEURL1B	hsa-miR-6833-3p	81.569	NM_001142651
NEURL1B	hsa-miR-3667-5p	81.1832	NM_001142651
NEURL1B	hsa-miR-4768-5p	81.1049	NM_001142651
NEURL1B	hsa-miR-5582-5p	80.8014	NM_001142651
NEURL1B	hsa-miR-761	80.6101	NM_001142651
NEURL1B	hsa-miR-214-3p	80.6101	NM_001142651

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Motifs and transcription factors (TFs) regulating NEURL1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NEURL1B	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."