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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NETO2

Summary for NETO2

Gene information	Gene symbol	NETO2
	Ensembl ID	ENSG00000171208
	Entrez ID	81831
	Gene name	neuropilin and tolloid like 2
	Synonyms	FLJ10430\|NEOT2
	Gene type	protein_coding
	UniProtAcc	Q8NC67

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Dataset with differentially expressed gene: NETO2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.360874	2.61e-16
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.33137	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.261897	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.345156	8.99e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.460762	4.78e-21
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.349657	2.51e-14
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.370359	4.96e-12
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.50633	0.00e+00

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Expression of NETO2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NETO2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NETO2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NETO2	hsa-miR-380-3p	99.1778	NM_001201477
NETO2	hsa-miR-411-3p	97.4976	NM_001201477
NETO2	hsa-miR-379-3p	97.4976	NM_001201477
NETO2	hsa-miR-4495	96.6333	NM_001201477
NETO2	hsa-miR-181a-2-3p	96.1871	NM_001201477
NETO2	hsa-miR-4251	96.1212	NM_001201477
NETO2	hsa-miR-144-3p	93.49	NM_001201477
NETO2	hsa-miR-488-3p	91.8689	NM_001201477
NETO2	hsa-miR-12136	91.1032	NM_001201477
NETO2	hsa-miR-7-2-3p	90.7136	NM_001201477
NETO2	hsa-miR-7-1-3p	90.7136	NM_001201477
NETO2	hsa-miR-516b-3p	90.4881	NM_001201477
NETO2	hsa-miR-7162-5p	90.4881	NM_001201477
NETO2	hsa-miR-516a-3p	90.4881	NM_001201477
NETO2	hsa-miR-409-5p	90.3	NM_001201477
NETO2	hsa-miR-6730-5p	90.1168	NM_001201477
NETO2	hsa-miR-223-5p	90.0669	NM_001201477
NETO2	hsa-miR-5692a	89.0338	NM_001201477
NETO2	hsa-miR-193a-5p	88.2394	NM_001201477
NETO2	hsa-miR-511-3p	87.1627	NM_001201477
NETO2	hsa-miR-1-3p	86.6679	NM_001201477
NETO2	hsa-miR-206	86.6679	NM_001201477
NETO2	hsa-miR-613	86.6112	NM_001201477
NETO2	hsa-miR-6073	86.4025	NM_001201477
NETO2	hsa-miR-5591-5p	85.7817	NM_001201477
NETO2	hsa-miR-4300	85.7817	NM_001201477
NETO2	hsa-miR-302c-5p	85.7111	NM_001201477
NETO2	hsa-miR-6509-3p	85.6783	NM_001201477
NETO2	hsa-miR-561-3p	85.0943	NM_001201477
NETO2	hsa-miR-6878-5p	84.5866	NM_001201477
NETO2	hsa-miR-1303	84.5538	NM_001201477
NETO2	hsa-miR-6761-5p	83.6202	NM_001201477
NETO2	hsa-miR-5701	83.3574	NM_001201477
NETO2	hsa-miR-6840-3p	83.2265	NM_001201477
NETO2	hsa-miR-8067	82.8355	NM_001201477
NETO2	hsa-miR-6508-5p	82.8355	NM_001201477
NETO2	hsa-miR-6726-5p	82.6777	NM_001201477
NETO2	hsa-miR-920	82.6777	NM_001201477
NETO2	hsa-miR-509-3p	82.6246	NM_001201477
NETO2	hsa-miR-651-3p	82.1665	NM_001201477
NETO2	hsa-miR-3646	81.7178	NM_001201477
NETO2	hsa-miR-4521	80.8687	NM_001201477

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Motifs and transcription factors (TFs) regulating NETO2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NETO2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NETO2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
NETO2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NETO2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NETO2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
NETO2	transfac_pro__M00652	NRF1 (directAnnotation).
NETO2	hdpi__ETV4	ETV4 (directAnnotation).
NETO2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NETO2	transfac_pro__M04866	HDAC2 (directAnnotation).
NETO2	jaspar__MA1122.1	TFDP1 (directAnnotation).
NETO2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
NETO2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
NETO2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
NETO2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
NETO2	jaspar__MA1483.2	ELF2 (directAnnotation).
NETO2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
NETO2	jaspar__MA1933.1	SREBF2 (directAnnotation).
NETO2	cisbp__M02645	ETS1 (directAnnotation).
NETO2	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
NETO2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NETO2	transfac_pro__M06331	ZNF343 (directAnnotation).
NETO2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
NETO2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
NETO2	hdpi__ELF2	ELF2 (directAnnotation).
NETO2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
NETO2	metacluster_183.4	ETS1 (inferredBy_Orthology).
NETO2	metacluster_81.7	CREB1 (directAnnotation).
NETO2	transfac_pro__M00492	STAT1 (directAnnotation).
NETO2	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
NETO2	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
NETO2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
NETO2	cisbp__M00808	MYPOP (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."