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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NETO1

Summary for NETO1

Gene information	Gene symbol	NETO1
	Ensembl ID	ENSG00000166342
	Entrez ID	81832
	Gene name	neuropilin and tolloid like 1
	Synonyms	BCTL1\|BTCL1
	Gene type	protein_coding
	UniProtAcc	Q8TDF5

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Dataset with differentially expressed gene: NETO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.786476	0.00e+00

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Expression of NETO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NETO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NETO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NETO1	hsa-miR-374a-5p	99.4279	NM_138999
NETO1	hsa-miR-374b-5p	99.2051	NM_138999
NETO1	hsa-miR-3163	99.1811	NM_138966
NETO1	hsa-miR-5692c	99.0883	NM_138999
NETO1	hsa-miR-5692b	99.0883	NM_138999
NETO1	hsa-miR-190a-3p	98.1747	NM_138966
NETO1	hsa-miR-5011-5p	97.1472	NM_138999
NETO1	hsa-miR-570-3p	96.507	NM_138966
NETO1	hsa-miR-548c-3p	94.9171	NM_138966
NETO1	hsa-miR-4760-3p	94.7751	NM_138966
NETO1	hsa-miR-889-3p	94.6553	NM_138999
NETO1	hsa-miR-3689f	94.3608	NM_138966
NETO1	hsa-miR-3689a-5p	94.3608	NM_138966
NETO1	hsa-miR-3689e	94.3608	NM_138966
NETO1	hsa-miR-3689b-5p	94.3608	NM_138966
NETO1	hsa-miR-5692a	94.1671	NM_138966
NETO1	hsa-miR-410-3p	94.1295	NM_138966
NETO1	hsa-miR-4643	93.9912	NM_001201465
NETO1	hsa-miR-4517	93.9094	NM_001201465
NETO1	hsa-miR-4801	93.3555	NM_138966
NETO1	hsa-miR-8063	93.2051	NM_138966
NETO1	hsa-miR-12124	93.1489	NM_138966
NETO1	hsa-miR-4659a-3p	92.996	NM_138966
NETO1	hsa-miR-4659b-3p	92.996	NM_138966
NETO1	hsa-miR-335-3p	92.2012	NM_138966
NETO1	hsa-miR-3662	91.501	NM_138966
NETO1	hsa-miR-137-3p	91.4865	NM_138966
NETO1	hsa-miR-4731-3p	91.3322	NM_138966
NETO1	hsa-miR-195-3p	91.322	NM_138999
NETO1	hsa-miR-16-2-3p	91.322	NM_138999
NETO1	hsa-miR-654-3p	91.3078	NM_138966
NETO1	hsa-miR-7152-5p	90.58	NM_138966
NETO1	hsa-miR-4790-3p	90.3477	NM_001201465
NETO1	hsa-miR-7-1-3p	90.1632	NM_138966
NETO1	hsa-miR-7-2-3p	90.1632	NM_138966
NETO1	hsa-miR-548an	89.8132	NM_138966
NETO1	hsa-miR-369-3p	89.7772	NM_138999
NETO1	hsa-miR-5003-3p	89.7651	NM_138966
NETO1	hsa-miR-141-5p	89.4078	NM_001201465
NETO1	hsa-miR-888-3p	89.3741	NM_138966
NETO1	hsa-miR-6072	89.3314	NM_001201465
NETO1	hsa-miR-4738-3p	89.2138	NM_138966
NETO1	hsa-miR-4534	89.0426	NM_138999
NETO1	hsa-miR-3613-3p	88.8749	NM_138966
NETO1	hsa-miR-4698	88.8082	NM_138966
NETO1	hsa-miR-5688	88.256	NM_138966
NETO1	hsa-miR-4753-3p	88.0063	NM_138966
NETO1	hsa-miR-153-5p	87.8332	NM_138966
NETO1	hsa-miR-6874-5p	87.7331	NM_138999
NETO1	hsa-miR-223-5p	87.5557	NM_138966

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Motifs and transcription factors (TFs) regulating NETO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NETO1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NETO1	transfac_pro__M02089	E2F3 (directAnnotation).
NETO1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NETO1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NETO1	transfac_pro__M04817	ZBTB33 (directAnnotation).
NETO1	metacluster_143.13	ZBTB7A (directAnnotation).
NETO1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
NETO1	tfdimers__MD00483	ZBTB14 (directAnnotation).
NETO1	cisbp__M07938	E2F1 (directAnnotation).
NETO1	cisbp__M00968	MTF2 (directAnnotation).
NETO1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
NETO1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NETO1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NETO1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NETO1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NETO1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."