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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NET1

Summary for NET1

Gene information	Gene symbol	NET1
	Ensembl ID	ENSG00000173848
	Entrez ID	10276
	Gene name	neuroepithelial cell transforming 1
	Synonyms	ARHGEF8\|NET1A
	Gene type	protein_coding
	UniProtAcc	Q7Z628

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Dataset with differentially expressed gene: NET1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.538451	1.45e-19
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.378223	1.53e-22
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.386883	3.61e-29

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Expression of NET1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NET1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NET1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating NET1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NET1	hsa-miR-22-3p	96.9818	NM_001047160
NET1	hsa-miR-8485	96.5001	NM_001047160
NET1	hsa-let-7a-2-3p	94.4011	NM_001047160
NET1	hsa-let-7g-3p	94.4011	NM_001047160
NET1	hsa-miR-5696	94.1051	NM_001047160
NET1	hsa-miR-4769-3p	93.0565	NM_001047160
NET1	hsa-miR-6817-5p	93.0565	NM_001047160
NET1	hsa-miR-5692a	92.1959	NM_001047160
NET1	hsa-miR-5093	91.8258	NM_005863
NET1	hsa-miR-548x-3p	89.0659	NM_005863
NET1	hsa-miR-548aj-3p	89.0659	NM_005863
NET1	hsa-miR-5011-5p	88.9646	NM_005863
NET1	hsa-miR-382-3p	88.9624	NM_005863
NET1	hsa-miR-579-3p	88.3931	NM_001047160
NET1	hsa-miR-664b-3p	88.3931	NM_001047160
NET1	hsa-miR-548ah-3p	87.4907	NM_005863
NET1	hsa-miR-548aq-3p	87.4907	NM_005863
NET1	hsa-miR-548ae-3p	87.4907	NM_005863
NET1	hsa-miR-548j-3p	87.4907	NM_005863
NET1	hsa-miR-548am-3p	87.4907	NM_005863
NET1	hsa-miR-29b-2-5p	86.7517	NM_005863
NET1	hsa-miR-7849-3p	86.7436	NM_005863
NET1	hsa-miR-613	86.3277	NM_001047160
NET1	hsa-miR-206	86.3277	NM_001047160
NET1	hsa-miR-1-3p	86.3277	NM_001047160
NET1	hsa-miR-8066	85.9798	NM_005863
NET1	hsa-miR-145-5p	85.942	NM_001047160
NET1	hsa-miR-5195-3p	85.942	NM_001047160
NET1	hsa-miR-3973	85.9207	NM_005863
NET1	hsa-miR-199b-3p	84.7626	NM_005863
NET1	hsa-miR-3129-5p	84.7626	NM_005863
NET1	hsa-miR-199a-3p	84.7626	NM_005863
NET1	hsa-miR-466	82.5357	NM_001047160
NET1	hsa-miR-95-5p	82.4217	NM_005863
NET1	hsa-miR-1277-5p	82.3537	NM_005863
NET1	hsa-miR-193a-5p	81.9507	NM_005863
NET1	hsa-miR-607	81.2889	NM_005863
NET1	hsa-miR-340-5p	81.1309	NM_001047160
NET1	hsa-miR-135a-5p	80.8483	NM_001047160
NET1	hsa-miR-135b-5p	80.8483	NM_001047160
NET1	hsa-miR-5087	80.2311	NM_001047160
NET1	hsa-miR-190a-3p	80.0819	NM_005863

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Motifs and transcription factors (TFs) regulating NET1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NET1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
NET1	transfac_pro__M06140	ZNF250 (directAnnotation).
NET1	metacluster_14.28	CLOCK (inferredBy_Orthology).
NET1	taipale_tf_pairs__TEAD4_MAX_RGAATGYNNACGTG_CAP_repr	MAX; TEAD4 (directAnnotation).
NET1	jaspar__MA0748.2	YY2 (directAnnotation).
NET1	tfdimers__MD00369	ZNF384 (directAnnotation).
NET1	transfac_pro__M04918	EGR1 (directAnnotation).
NET1	transfac_pro__M06173	ZNF85 (directAnnotation).
NET1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
NET1	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
NET1	tfdimers__MD00364	WT1 (directAnnotation).
NET1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."