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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NEMF

Summary for NEMF

Gene information	Gene symbol	NEMF
	Ensembl ID	ENSG00000165525
	Entrez ID	9147
	Gene name	nuclear export mediator factor
	Synonyms	FLJ10051\|NY-CO-1\|RQC2\|SDCCAG1
	Gene type	protein_coding
	UniProtAcc	O60524

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Dataset with differentially expressed gene: NEMF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.628424	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.28498	2.62e-34
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.386094	0.00e+00

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Expression of NEMF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NEMF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NEMF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NEMF	hsa-miR-5011-5p	99.9967	NM_004713
NEMF	hsa-miR-1277-5p	99.7417	NM_004713
NEMF	hsa-miR-3059-5p	99.698	NM_004713
NEMF	hsa-miR-4708-3p	99.5141	NM_004713
NEMF	hsa-miR-190a-3p	99.3431	NM_004713
NEMF	hsa-miR-5683	98.3066	NM_004713
NEMF	hsa-miR-5009-3p	96.1101	NM_001301732
NEMF	hsa-miR-3171	95.3485	NM_004713
NEMF	hsa-miR-520e-5p	95.1118	NM_004713
NEMF	hsa-miR-3163	94.9019	NM_001301732
NEMF	hsa-miR-4668-5p	94.7642	NM_004713
NEMF	hsa-miR-204-3p	94.381	NM_004713
NEMF	hsa-miR-4646-5p	94.381	NM_004713
NEMF	hsa-miR-548ar-3p	94.289	NM_001301732
NEMF	hsa-miR-372-5p	92.768	NM_004713
NEMF	hsa-miR-3691-3p	92.0992	NM_004713
NEMF	hsa-miR-548bc	91.0768	NM_001301732
NEMF	hsa-miR-548az-3p	91.0768	NM_001301732
NEMF	hsa-miR-548a-3p	91.0768	NM_001301732
NEMF	hsa-miR-548e-3p	91.0768	NM_001301732
NEMF	hsa-miR-548f-3p	91.0768	NM_001301732
NEMF	hsa-miR-498-5p	89.7821	NM_004713
NEMF	hsa-miR-3646	89.4198	NM_001301732
NEMF	hsa-miR-5692b	87.4354	NM_004713
NEMF	hsa-miR-5692c	87.4354	NM_004713
NEMF	hsa-miR-203a-3p	87.2073	NM_001301732
NEMF	hsa-miR-12124	86.7626	NM_001301732
NEMF	hsa-miR-6735-3p	86.2206	NM_004713
NEMF	hsa-miR-153-5p	84.6018	NM_004713
NEMF	hsa-miR-3927-5p	80.1597	NM_004713

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Motifs and transcription factors (TFs) regulating NEMF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NEMF	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NEMF	cisbp__M00808	MYPOP (inferredBy_Orthology).
NEMF	cisbp__M08198	ELF1 (directAnnotation).
NEMF	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
NEMF	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
NEMF	metacluster_111.5	E4F1; E4F1 (directAnnotation).
NEMF	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
NEMF	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NEMF	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
NEMF	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
NEMF	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
NEMF	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NEMF	transfac_pro__M02913	SP140 (inferredBy_Orthology).
NEMF	transfac_pro__M01861	ATF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."