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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NELL2

Summary for NELL2

Gene information	Gene symbol	NELL2
	Ensembl ID	ENSG00000184613
	Entrez ID	4753
	Gene name	neural EGFL like 2
	Synonyms	NRP2
	Gene type	protein_coding
	UniProtAcc	Q99435

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Dataset with differentially expressed gene: NELL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.283331	0.00e+00

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Expression of NELL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NELL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NELL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NELL2	hsa-miR-539-5p	96.0784	NM_001145107
NELL2	hsa-miR-6811-3p	93.9997	NM_001145107
NELL2	hsa-miR-4724-5p	93.9123	NM_001145108
NELL2	hsa-miR-544a	91.524	NM_001145107
NELL2	hsa-miR-143-5p	91.417	NM_001145107
NELL2	hsa-miR-507	91.1507	NM_001145108
NELL2	hsa-miR-519a-3p	90.6688	NM_001145107
NELL2	hsa-miR-519b-3p	90.6688	NM_001145107
NELL2	hsa-miR-519c-3p	90.6688	NM_001145107
NELL2	hsa-miR-1914-5p	89.7566	NM_001145107
NELL2	hsa-miR-6890-3p	89.3394	NM_001145107
NELL2	hsa-miR-133b	88.4121	NM_001145107
NELL2	hsa-miR-133a-3p	88.4121	NM_001145107
NELL2	hsa-miR-214-5p	88.1399	NM_001145107
NELL2	hsa-miR-557	87.8466	NM_001145108
NELL2	hsa-miR-520g-5p	87.8238	NM_001145108
NELL2	hsa-miR-6843-3p	87.6943	NM_001145107
NELL2	hsa-miR-6848-3p	87.6943	NM_001145107
NELL2	hsa-miR-548ba	84.4048	NM_001145108
NELL2	hsa-miR-548ag	84.4048	NM_001145108
NELL2	hsa-miR-548ai	84.4048	NM_001145108
NELL2	hsa-miR-570-5p	84.4048	NM_001145108
NELL2	hsa-miR-7-2-3p	82.3516	NM_001145107
NELL2	hsa-miR-7-1-3p	82.3516	NM_001145107
NELL2	hsa-miR-6514-3p	82.2333	NM_001145107
NELL2	hsa-miR-3928-3p	81.6226	NM_001145107
NELL2	hsa-miR-4766-5p	80.6983	NM_001145107
NELL2	hsa-miR-3130-3p	80.4519	NM_001145108

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Motifs and transcription factors (TFs) regulating NELL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NELL2	transfac_pro__M07317	CTBP1 (directAnnotation).
NELL2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NELL2	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
NELL2	hdpi__GTF3C2	GTF3C2 (directAnnotation).
NELL2	metacluster_198.3	ZFP64 (directAnnotation).
NELL2	transfac_pro__M04646	FOXN4 (directAnnotation).
NELL2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."