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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NEK2

Summary for NEK2

Gene information	Gene symbol	NEK2
	Ensembl ID	ENSG00000117650
	Entrez ID	4751
	Gene name	NIMA related kinase 2
	Synonyms	NEK2A\|NLK1\|PPP1R111\|RP67
	Gene type	protein_coding
	UniProtAcc	P51955

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Dataset with differentially expressed gene: NEK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.05108	4.11e-04
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.27696	7.13e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.328648	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.26444	6.27e-27

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Expression of NEK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NEK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NEK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NEK2	hsa-miR-491-3p	95.1407	NM_001204182
NEK2	hsa-miR-7106-5p	93.9766	NM_001204182
NEK2	hsa-miR-128-3p	93.7214	NM_002497
NEK2	hsa-miR-216a-3p	93.7214	NM_002497
NEK2	hsa-miR-4727-3p	93.204	NM_002497
NEK2	hsa-miR-370-5p	92.284	NM_001204182
NEK2	hsa-miR-616-5p	90.9774	NM_001204183
NEK2	hsa-miR-373-5p	90.9774	NM_001204183
NEK2	hsa-miR-371b-5p	90.9774	NM_001204183
NEK2	hsa-miR-2116-5p	90.8427	NM_002497
NEK2	hsa-miR-3681-3p	90.7006	NM_002497
NEK2	hsa-miR-4666a-5p	90.6554	NM_001204182
NEK2	hsa-miR-18b-3p	90.4641	NM_001204183
NEK2	hsa-miR-499b-5p	89.1866	NM_002497
NEK2	hsa-miR-3157-3p	88.6618	NM_001204183
NEK2	hsa-miR-4677-5p	87.907	NM_002497
NEK2	hsa-miR-12123	87.6387	NM_001204182
NEK2	hsa-miR-629-3p	87.2789	NM_002497
NEK2	hsa-miR-4713-5p	87.1526	NM_002497
NEK2	hsa-miR-4317	87.0663	NM_001204183
NEK2	hsa-miR-6074	86.7469	NM_001204183
NEK2	hsa-miR-3074-3p	85.2219	NM_001204182
NEK2	hsa-miR-3153	85.1348	NM_002497
NEK2	hsa-miR-1827	85.0009	NM_001204183
NEK2	hsa-miR-146a-3p	82.6737	NM_001204183
NEK2	hsa-miR-548ag	81.6206	NM_001204183
NEK2	hsa-miR-548ai	81.6206	NM_001204183
NEK2	hsa-miR-548ba	81.6206	NM_001204183
NEK2	hsa-miR-570-5p	81.6206	NM_001204183
NEK2	hsa-miR-6501-3p	81.4029	NM_002497
NEK2	hsa-miR-4310	81.3853	NM_002497
NEK2	hsa-miR-6817-3p	80.6625	NM_001204183
NEK2	hsa-miR-4264	80.0732	NM_002497
NEK2	hsa-miR-499a-3p	80.0386	NM_002497
NEK2	hsa-miR-499b-3p	80.0386	NM_002497

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Motifs and transcription factors (TFs) regulating NEK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NEK2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
NEK2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NEK2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NEK2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NEK2	"5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxam	DB07180	small molecule
NEK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."