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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: NEFM

Summary for NEFM

Gene informationGene symbol

NEFM

Ensembl ID

ENSG00000104722

Entrez ID

4741

Gene nameneurofilament medium chain
SynonymsNEF3|NF-M|NFM
Gene typeprotein_coding
UniProtAcc

P07197


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Dataset with differentially expressed gene: NEFM

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells-1.491181.38e-06

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells2.496060.00e+00

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Expression of NEFM in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to NEFM

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NEFM

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
NEFMhsa-miR-92b-3p96.5437NM_001105541
NEFMhsa-miR-32-5p96.5437NM_001105541
NEFMhsa-miR-92a-3p96.5437NM_001105541
NEFMhsa-miR-363-3p96.3627NM_001105541
NEFMhsa-miR-367-3p96.3627NM_001105541
NEFMhsa-miR-25-3p96.3627NM_001105541
NEFMhsa-miR-6759-3p94.9169NM_001105541
NEFMhsa-miR-1212390.9478NM_001105541
NEFMhsa-miR-24-3p89.9225NM_001105541
NEFMhsa-miR-58689.8376NM_001105541
NEFMhsa-miR-3160-5p89.4702NM_001105541
NEFMhsa-miR-480386.3086NM_001105541
NEFMhsa-miR-135a-5p84.2311NM_001105541
NEFMhsa-miR-135b-5p84.2311NM_001105541
NEFMhsa-miR-30e-5p83.6976NM_001105541
NEFMhsa-miR-30b-5p83.6976NM_001105541
NEFMhsa-miR-30d-5p83.6976NM_001105541
NEFMhsa-miR-30a-5p83.6976NM_001105541
NEFMhsa-miR-30c-5p83.6976NM_001105541
NEFMhsa-miR-6507-3p82.9836NM_001105541
NEFMhsa-miR-4726-3p82.3688NM_001105541
NEFMhsa-miR-2681-3p80.2862NM_001105541
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Motifs and transcription factors (TFs) regulating NEFM

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
NEFMtaipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
NEFMkznf__ZNF25_Imbeault2017_OM_MEMEZNF25 (directAnnotation).
NEFMtaipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAPETV5; HES7 (directAnnotation).
NEFMkznf__ZFP57_Imbeault2017_RP_ChIP-seqZFP57 (directAnnotation).
NEFMkznf__ZNF777_Imbeault2017_RP_ChIP-seqZNF777 (directAnnotation).
NEFMmetacluster_195.2EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
NEFMmetacluster_67.2ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
NEFMmetacluster_3.14WT1; WT1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."