Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NEFL

Summary for NEFL

Gene information	Gene symbol	NEFL
	Ensembl ID	ENSG00000277586
	Entrez ID	4747
	Gene name	neurofilament light chain
	Synonyms	CMT1F\|CMT2E\|NF68\|NFL\|PPP1R110
	Gene type	protein_coding
	UniProtAcc	P07196

Top

Dataset with differentially expressed gene: NEFL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.751664	0.00e+00

Top

Expression of NEFL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NEFL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NEFL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NEFL	hsa-miR-3140-5p	98.5103	NM_006158
NEFL	hsa-miR-4699-3p	96.5131	NM_006158
NEFL	hsa-miR-92a-3p	93.5536	NM_006158
NEFL	hsa-miR-92b-3p	93.5536	NM_006158
NEFL	hsa-miR-32-5p	93.5536	NM_006158
NEFL	hsa-miR-585-5p	93.1703	NM_006158
NEFL	hsa-miR-5003-5p	93.1375	NM_006158
NEFL	hsa-miR-25-3p	91.9736	NM_006158
NEFL	hsa-miR-363-3p	91.9736	NM_006158
NEFL	hsa-miR-367-3p	91.9736	NM_006158
NEFL	hsa-miR-208a-5p	91.6615	NM_006158
NEFL	hsa-miR-208b-5p	91.6615	NM_006158
NEFL	hsa-miR-3143	91.1524	NM_006158
NEFL	hsa-miR-302c-5p	88.7429	NM_006158
NEFL	hsa-miR-330-3p	87.5145	NM_006158
NEFL	hsa-miR-190a-3p	86.7449	NM_006158
NEFL	hsa-miR-6796-5p	86.4199	NM_006158
NEFL	hsa-miR-4330	86.375	NM_006158
NEFL	hsa-miR-507	85.5727	NM_006158
NEFL	hsa-miR-183-5p	85.4688	NM_006158
NEFL	hsa-miR-708-3p	85.2442	NM_006158
NEFL	hsa-miR-30c-5p	83.9357	NM_006158
NEFL	hsa-miR-30a-5p	83.9357	NM_006158
NEFL	hsa-miR-30e-5p	83.9357	NM_006158
NEFL	hsa-miR-30d-5p	83.9357	NM_006158
NEFL	hsa-miR-30b-5p	83.9357	NM_006158
NEFL	hsa-miR-583	83.494	NM_006158
NEFL	hsa-miR-4714-5p	83.3486	NM_006158
NEFL	hsa-miR-12135	82.371	NM_006158
NEFL	hsa-miR-23a-3p	82.2743	NM_006158
NEFL	hsa-miR-23c	82.2743	NM_006158
NEFL	hsa-miR-23b-3p	82.2743	NM_006158
NEFL	hsa-miR-7702	81.9649	NM_006158
NEFL	hsa-miR-514a-5p	81.5666	NM_006158
NEFL	hsa-miR-545-5p	81.4711	NM_006158
NEFL	hsa-miR-3661	80.1896	NM_006158

Page: 1

Top

Motifs and transcription factors (TFs) regulating NEFL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NEFL	jaspar__MA1957.1	ELK1 (directAnnotation).
NEFL	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
NEFL	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
NEFL	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."