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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NEDD4

Summary for NEDD4

Gene information	Gene symbol	NEDD4
	Ensembl ID	ENSG00000069869
	Entrez ID	4734
	Gene name	NEDD4 E3 ubiquitin protein ligase
	Synonyms	KIAA0093\|MGC176705\|NEDD4-1\|RPF1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NEDD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.26561	6.30e-16

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Expression of NEDD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NEDD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NEDD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NEDD4	hsa-miR-5011-5p	99.7692	NM_001284338
NEDD4	hsa-miR-30a-5p	98.1227	NM_001284338
NEDD4	hsa-miR-30b-5p	98.1227	NM_001284338
NEDD4	hsa-miR-30e-5p	98.1227	NM_001284338
NEDD4	hsa-miR-30d-5p	98.1227	NM_001284338
NEDD4	hsa-miR-30c-5p	98.1227	NM_001284338
NEDD4	hsa-miR-190a-3p	98.107	NM_001284338
NEDD4	hsa-miR-3609	97.5449	NM_001284338
NEDD4	hsa-miR-548ah-5p	96.898	NM_001284338
NEDD4	hsa-miR-548t-5p	96.012	NM_001284338
NEDD4	hsa-miR-548az-5p	96.012	NM_001284338
NEDD4	hsa-miR-520e-5p	95.8808	NM_001284338
NEDD4	hsa-miR-8062	95.6443	NM_001284338
NEDD4	hsa-miR-4719	94.4874	NM_001284338
NEDD4	hsa-miR-4735-3p	94.3533	NM_001284338
NEDD4	hsa-miR-18a-5p	93.9855	NM_001284338
NEDD4	hsa-miR-18b-5p	93.9855	NM_001284338
NEDD4	hsa-miR-4310	93.9055	NM_001284338
NEDD4	hsa-miR-487b-5p	93.7111	NM_001284338
NEDD4	hsa-miR-487a-5p	93.7111	NM_001284338
NEDD4	hsa-miR-7157-5p	93.6693	NM_001284338
NEDD4	hsa-miR-655-3p	92.4919	NM_001284338
NEDD4	hsa-miR-374c-5p	91.2565	NM_001284338
NEDD4	hsa-miR-1283	91.1017	NM_001284338
NEDD4	hsa-miR-2115-3p	90.9888	NM_001284338
NEDD4	hsa-miR-1298-3p	90.1139	NM_001284338
NEDD4	hsa-miR-6763-3p	89.7588	NM_001284338
NEDD4	hsa-miR-3129-5p	88.5057	NM_001284338
NEDD4	hsa-miR-199a-3p	88.5057	NM_001284338
NEDD4	hsa-miR-199b-3p	88.5057	NM_001284338
NEDD4	hsa-miR-1244	87.2194	NM_001284338
NEDD4	hsa-miR-4698	86.9695	NM_001284338
NEDD4	hsa-miR-9-5p	85.511	NM_001284338
NEDD4	hsa-miR-3977	85.3828	NM_001284338
NEDD4	hsa-miR-7853-5p	84.8627	NM_001284338
NEDD4	hsa-miR-105-5p	84.8627	NM_001284338
NEDD4	hsa-miR-6826-5p	84.0103	NM_001284338
NEDD4	hsa-miR-27b-3p	83.9176	NM_001284338
NEDD4	hsa-miR-9985	83.9176	NM_001284338
NEDD4	hsa-miR-27a-3p	83.9176	NM_001284338
NEDD4	hsa-miR-4797-3p	83.3325	NM_001284338
NEDD4	hsa-miR-4752	83.1966	NM_001284338
NEDD4	hsa-miR-5003-3p	81.134	NM_001284338
NEDD4	hsa-miR-3185	80.6683	NM_001284338

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Motifs and transcription factors (TFs) regulating NEDD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NEDD4	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
NEDD4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NEDD4	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
NEDD4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NEDD4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NEDD4	cisbp__M00249	WT1 (directAnnotation).
NEDD4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NEDD4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NEDD4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NEDD4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."